(2S,4S)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate

Modify Date: 2024-01-03 14:05:39

(2S,4S)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate structure	Common Name	(2S,4S)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate
	CAS Number	102195-79-9	Molecular Weight	245.272
	Density	1.2±0.1 g/cm3	Boiling Point	335.2±42.0 °C at 760 mmHg
	Molecular Formula	C₁₁H₁₉NO₅	Melting Point	82-86ºC
	MSDS	Chinese USA	Flash Point	156.6±27.9 °C
	Symbol	GHS07	Signal Word	Warning

Use of (2S,4S)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate

N-Boc-cis-4-hydroxy-L-proline methyl ester is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Boc-cis-4-hydroxy-L-proline methyl ester is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2

Name	N-Boc-cis-4-hydroxy-L-proline Methyl Ester
Synonym	More Synonyms

Description	N-Boc-cis-4-hydroxy-L-proline methyl ester is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Boc-cis-4-hydroxy-L-proline methyl ester is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Non-cleavable
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References	[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Density	1.2±0.1 g/cm3
Boiling Point	335.2±42.0 °C at 760 mmHg
Melting Point	82-86ºC
Molecular Formula	C₁₁H₁₉NO₅
Molecular Weight	245.272
Flash Point	156.6±27.9 °C
Exact Mass	245.126328
PSA	76.07000
LogP	-0.25
Vapour Pressure	0.0±1.6 mmHg at 25°C
Index of Refraction	1.501
Storage condition	-15°C

MSDS(Chinese)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H317-H319-H335
Precautionary Statements	P261-P280-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xn:Harmful;
Risk Phrases	R22;R36/37/38;R43
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	2
HS Code	2933990090

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%