2-Demethyl Colchicine

Modify Date: 2025-09-07 13:45:34

2-Demethyl Colchicine Structure
2-Demethyl Colchicine structure
Common Name 2-Demethyl Colchicine
CAS Number 102491-80-5 Molecular Weight 385.41000
Density 1.31g/cm3 Boiling Point 766.1ºC at 760 mmHg
Molecular Formula C21H23NO6 Melting Point 166-168ºC
MSDS N/A Flash Point 417.1ºC

 Names

Name 2-Demethyl Colchicine
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.31g/cm3
Boiling Point 766.1ºC at 760 mmHg
Melting Point 166-168ºC
Molecular Formula C21H23NO6
Molecular Weight 385.41000
Flash Point 417.1ºC
Exact Mass 385.15300
PSA 94.09000
LogP 2.95950
Vapour Pressure 2.63E-24mmHg at 25°C
Index of Refraction 1.61

 Synthetic Route

~48%

2-Demethyl Colchicine Structure

2-Demethyl Colc...

CAS#:102491-80-5

Literature: Dumont; Brossi; Silverton Journal of Organic Chemistry, 1986 , vol. 51, # 13 p. 2515 - 2521

 Precursor & DownStream

Precursor  1

DownStream  0

 2-Demethyl ColchicineBioassay

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Name: HIV Cellular Data
Source: NIAID
Target: N/A
External Id: HIV Cellular Data
Name: Dose of compound which caused an average weight loss >3g in a set of mice or the deat...
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL728139
Name: Cytotoxicity against human H9 cells
Source: ChEMBL
Target: H9
External Id: CHEMBL1019291
Name: Antiviral activity against HIV1 HTLV-3B in human H9 cells after 3 days by p24 antigen...
Source: ChEMBL
Target: Human immunodeficiency virus 1
External Id: CHEMBL1019290
Name: Antileishmanial activity against Leishmania major amastigotes assessed as reduction i...
Source: ChEMBL
Target: Leishmania major
External Id: CHEMBL5532822
Name: Antileishmanial activity against Leishmania major promastigotes assessed as reduction...
Source: ChEMBL
Target: Leishmania major
External Id: CHEMBL5532821
Name: Percentage by which the binding of [3H]colchicine (2.5 uM) to tubulin from calf brain...
Source: ChEMBL
Target: Tubulin beta-2B chain
External Id: CHEMBL815056
Name: Percentage inhibition of multi drug resistant KB subclone growth expressing P-glycopr...
Source: ChEMBL
Target: KB 3-1
External Id: CHEMBL827698
Name: Inhibition of [3H]colchicine binding to microtubule protein tubulin
Source: ChEMBL
Target: Tubulin alpha-3C chain
External Id: CHEMBL820637
Name: In vitro cytotoxic activity against human lung carcinoma (A549) tumor cell line
Source: ChEMBL
Target: N/A
External Id: CHEMBL837543
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 Synonyms

3-Desmethyl-colchicin
3-bromo-benzoic acid,deprotonated form
2-Demethyl-colchicin
3-Demethyl-colchicin
3-Desmethyl-colchicein
3-Brom-benzoesaeure-Anion
O2-Demethyl-colchicin
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