E1231
Modify Date: 2024-10-11 15:48:26
E1231 structure
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Common Name | E1231 | ||
|---|---|---|---|---|
| CAS Number | 1031195-19-3 | Molecular Weight | 363.410 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 605.8±55.0 °C at 760 mmHg | |
| Molecular Formula | C21H21N3O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 320.2±31.5 °C | |
Use of E1231E1231 (E-1231) is a small molecule SIRT1 activator with EC50 of 0.83 uM, interactes with recombinant human SIRT1 protein and deacetylated liver X receptor-alpha (LXRα); increases ATP-binding cassette transporter A1 (ABCA1) expression in RAW 264.7 cells dependent on SIRT1 and LXRα, promotes cholesterol efflux and inhibited lipid accumulation in RAW 264.7 cells via SIRT1 and ABCA1; decreases total cholesterol and triglyceride levels in both serum and the liver in golden hamster hyperlipidemia models. |
| Name | 1-(4-{[2-(5-Methyl-2-furyl)-4-quinolinyl]carbonyl}-1-piperazinyl)ethanone |
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| Synonym | More Synonyms |
| Description | E1231 (E-1231) is a small molecule SIRT1 activator with EC50 of 0.83 uM, interactes with recombinant human SIRT1 protein and deacetylated liver X receptor-alpha (LXRα); increases ATP-binding cassette transporter A1 (ABCA1) expression in RAW 264.7 cells dependent on SIRT1 and LXRα, promotes cholesterol efflux and inhibited lipid accumulation in RAW 264.7 cells via SIRT1 and ABCA1; decreases total cholesterol and triglyceride levels in both serum and the liver in golden hamster hyperlipidemia models. |
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| References | References 1. Feng T, et al. Atherosclerosis. 2018 Jul;274:172-181. View Related Products by Target Sirtuin |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 605.8±55.0 °C at 760 mmHg |
| Molecular Formula | C21H21N3O3 |
| Molecular Weight | 363.410 |
| Flash Point | 320.2±31.5 °C |
| Exact Mass | 363.158295 |
| LogP | 1.30 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.626 |
| MFCD10627184 |
| 1-(4-{[2-(5-Methyl-2-furyl)-4-quinolinyl]carbonyl}-1-piperazinyl)ethanone |
| Ethanone, 1-[4-[[2-(5-methyl-2-furanyl)-4-quinolinyl]carbonyl]-1-piperazinyl]- |