ALZ-801

Modify Date: 2025-08-22 00:47:54

ALZ-801 Structure
ALZ-801 structure
Common Name ALZ-801
CAS Number 1034190-08-3 Molecular Weight 238.302
Density N/A Boiling Point N/A
Molecular Formula C8H18N2O4S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of ALZ-801


ALZ-801 is an orally available, small-molecule β-amyloid (Aβ) anti-oligomer and aggregation inhibitor, valine-conjugated prodrug of Tramiprosate with substantially improved PK properties and gastrointestinal tolerability compared with the parent compound[1]. ALZ-801 is an advanced and markedly improved clinical candidate for the treatment of Alzheimer’s disease[2].

 Names

Name GHG2B47067
Synonym More Synonyms

 ALZ-801 Biological Activity

Description ALZ-801 is an orally available, small-molecule β-amyloid (Aβ) anti-oligomer and aggregation inhibitor, valine-conjugated prodrug of Tramiprosate with substantially improved PK properties and gastrointestinal tolerability compared with the parent compound[1]. ALZ-801 is an advanced and markedly improved clinical candidate for the treatment of Alzheimer’s disease[2].
Related Catalog
Target

β-amyloid[1]

References

[1]. John A. Hey, et al. Discovery and Identification of an Endogenous Metabolite of Tramiprosate and Its Prodrug ALZ-801 that Inhibits Beta Amyloid Oligomer Formation in the Human Brain. CNS Drugs. 2018; 32(9): 849–861.

[2]. Hey JA, et al. Clinical Pharmacokinetics and Safety of ALZ-801, a Novel Prodrug of Tramiprosate in Development for the Treatment of Alzheimer's Disease. Clin Pharmacokinet. 2018 Mar;57(3):315-333.

 Chemical & Physical Properties

Molecular Formula C8H18N2O4S
Molecular Weight 238.302

 Synonyms

GHG2B47067
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