CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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VD4830000
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CHEMICAL NAME :
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3-Quinuclidinemethanol, alpha,alpha-diphenyl-, hydrochloride
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CAS REGISTRY NUMBER :
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10447-38-8
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LAST UPDATED :
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199603
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DATA ITEMS CITED :
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4
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MOLECULAR FORMULA :
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C20-H23-N-O.Cl-H
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MOLECULAR WEIGHT :
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329.90
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WISWESSER LINE NOTATION :
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T66 A B CNTJ AXQR&R &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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440 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 40,42,1977
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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370 mg/kg
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TOXIC EFFECTS :
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Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea
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REFERENCE :
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RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 40,42,1977
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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62 mg/kg
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TOXIC EFFECTS :
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Behavioral - somnolence (general depressed activity)
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REFERENCE :
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RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 40,42,1977
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - guinea pig
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DOSE/DURATION :
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860 mg/kg
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TOXIC EFFECTS :
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Vascular - BP elevation not characterized in autonomic section Lungs, Thorax, or Respiration - bronchiolar dilation Immunological Including Allergic - increased immune response
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REFERENCE :
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FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 43,148,1980
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