3-(7-hydroxy-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione
Modify Date: 2025-08-25 20:23:39
3-(7-hydroxy-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione structure
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Common Name | 3-(7-hydroxy-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione | ||
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| CAS Number | 1061604-41-8 | Molecular Weight | 260.245 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 602.9±55.0 °C at 760 mmHg | |
| Molecular Formula | C13H12N2O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 318.4±31.5 °C | |
Use of 3-(7-hydroxy-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dioneLenalidomide-4-OH is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-4-OH can be connected to the ligand for protein by a linker to form PROTAC. |
| Name | 3-(7-hydroxy-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione |
|---|---|
| Synonym | More Synonyms |
| Description | Lenalidomide-4-OH is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-4-OH can be connected to the ligand for protein by a linker to form PROTAC. |
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| Related Catalog | |
| Target |
Cereblon |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 602.9±55.0 °C at 760 mmHg |
| Molecular Formula | C13H12N2O4 |
| Molecular Weight | 260.245 |
| Flash Point | 318.4±31.5 °C |
| Exact Mass | 260.079712 |
| LogP | -0.85 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.660 |
| InChIKey | HGPRKOYQOBYISD-UHFFFAOYSA-N |
| SMILES | O=C1CCC(N2Cc3c(O)cccc3C2=O)C(=O)N1 |
| Storage condition | 2-8℃ |
| MFCD29054753 |
| 3-(4-Hydroxy-1-oxo-1,3-dihydro-2H-isoindol-2-yl)-2,6-piperidinedione |
| 2,6-Piperidinedione, 3-(1,3-dihydro-4-hydroxy-1-oxo-2H-isoindol-2-yl)- |