mTOR inhibitor WYE-28

Modify Date: 2024-01-11 22:10:41

mTOR inhibitor WYE-28 Structure
mTOR inhibitor WYE-28 structure
 Common Name mTOR inhibitor WYE-28
CAS Number 1062172-60-4 Molecular Weight 586.64
Density N/A Boiling Point N/A
Molecular Formula C30H34N8O5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of mTOR inhibitor WYE-28


mTOR inhibitor WYE-28 (compound 28) is a selective inhibitor of mTOR>/b< (IC50)=0.08 nM. mTOR inhibitor WYE-28 inhibits PI3Kα with an IC50 value of 6 nM. mTOR inhibitor WYE-28 shows a metabolic time (T1/2) in nude mouse microsomes of 13 min[1].

 Names

Name mTOR inhibitor WYE-28

 mTOR inhibitor WYE-28 Biological Activity

Description mTOR inhibitor WYE-28 (compound 28) is a selective inhibitor of mTOR>/b< (IC50)=0.08 nM. mTOR inhibitor WYE-28 inhibits PI3Kα with an IC50 value of 6 nM. mTOR inhibitor WYE-28 shows a metabolic time (T1/2) in nude mouse microsomes of 13 min[1].
Related Catalog
References

[1]. Zask A, et al. ATP-competitive inhibitors of the mammalian target of rapamycin: design and synthesis of highly potent and selective pyrazolopyrimidines. J Med Chem. 2009 Aug 27;52(16):5013-6.  

 Chemical & Physical Properties

Molecular Formula C30H34N8O5
Molecular Weight 586.64
InChIKey DLIGFKRUAOAIBA-UHFFFAOYSA-N
SMILES COC(=O)N1CCC(n2ncc3c(N4CCOCC4)nc(-c4ccc(NC(=O)Nc5ccc(CO)cc5)cc4)nc32)CC1
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Chemsrc provides mTOR inhibitor WYE-28(CAS#:1062172-60-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of mTOR inhibitor WYE-28 are included as well.>> amp version: mTOR inhibitor WYE-28

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