D-Boc valine methyl ester

Modify Date: 2024-01-29 13:47:39

D-Boc valine methyl ester structure	Common Name	D-Boc valine methyl ester
	CAS Number	106391-85-9	Molecular Weight	231.28900
	Density	1.02g/cm3	Boiling Point	306.042°C at 760 mmHg
	Molecular Formula	C₁₁H₂₁NO₄	Melting Point	N/A
	MSDS	N/A	Flash Point	138.889°C

Use of D-Boc valine methyl ester

D-Boc Valine methyl ester is an intermediate in the synthesis of Taltobulin (HY-15584). Taltobulin is a common toxin component in ADC preparation (ADC Cytotoxin), and it is also a powerful tubulin (Microtubule/Tubulin) inhibitor. Taltobulin disrupts tubulin polymerization, induces mitotic arrest, and induces apoptosis[1].

Name	D-Boc valine methyl ester
Synonym	More Synonyms

Description	D-Boc Valine methyl ester is an intermediate in the synthesis of Taltobulin (HY-15584). Taltobulin is a common toxin component in ADC preparation (ADC Cytotoxin), and it is also a powerful tubulin (Microtubule/Tubulin) inhibitor. Taltobulin disrupts tubulin polymerization, induces mitotic arrest, and induces apoptosis[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. Loganzo F, et al. HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Cancer Res. 2003 Apr 15;63(8):1838-45.

Density	1.02g/cm3
Boiling Point	306.042°C at 760 mmHg
Molecular Formula	C₁₁H₂₁NO₄
Molecular Weight	231.28900
Flash Point	138.889°C
Exact Mass	231.14700
PSA	64.63000
LogP	2.09960
Index of Refraction	1.442

HS Code	2924199090

Precursor 0
DownStream 4
CAS#:86695-06-9 (2R)-2-Amino-3-... CAS#:7146-15-8 H-D-Val-OMe.HCl CAS#:191090-32-1 (R)-(+)-4-Isopr... CAS#:223906-38-5 (R)-(+)-4-ISOPR...

HS Code	2924199090
Summary	2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%