Tafenoquine
Modify Date: 2024-01-02 20:47:57
Tafenoquine structure
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Common Name | Tafenoquine | ||
|---|---|---|---|---|
| CAS Number | 106635-80-7 | Molecular Weight | 463.49300 | |
| Density | 1.237g/cm3 | Boiling Point | 565.6ºC at 760mmHg | |
| Molecular Formula | C24H28F3N3O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 295.9ºC | |
Use of TafenoquineTafenoquine (WR 238605) is an 8-aminoquinoline. Tafenoquine is an anti-malarial prophylactic agent[1]. |
| Name | 4-N-[2,6-dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]quinolin-8-yl]pentane-1,4-diamine |
|---|---|
| Synonym | More Synonyms |
| Description | Tafenoquine (WR 238605) is an 8-aminoquinoline. Tafenoquine is an anti-malarial prophylactic agent[1]. |
|---|---|
| Related Catalog | |
| Target |
Anti-malarial[1] |
| In Vivo | Tafenoquine exhibits no anti-malarial activity in CYP 2D knock-out mice when dosed at their ED100 values (3 mg/kg) established in WT mice. Tafenoquine anti-malarial activity is partially restored in humanized/CYP 2D6 knock-in mice when tested at two times its ED100 (6 mg/kg)[1]. |
| References |
| Density | 1.237g/cm3 |
|---|---|
| Boiling Point | 565.6ºC at 760mmHg |
| Molecular Formula | C24H28F3N3O3 |
| Molecular Weight | 463.49300 |
| Flash Point | 295.9ºC |
| Exact Mass | 463.20800 |
| PSA | 78.63000 |
| LogP | 6.68410 |
| Vapour Pressure | 8.17E-13mmHg at 25°C |
| Index of Refraction | 1.572 |
| Storage condition | 2-8℃ |
| 8-<(4-amino-1-methylbutyl)amino>-2,6-dimethoxy-4-methyl-5-<3-(trifluoromethyl)phenoxy>quinoline |
| Tafenoquine |
| N(4)-(2,6-Dimethoxy-4-methyl-5-((3-trifluoromethyl)phenoxy)-8-quinolinyl)-1,4-pentanediamine |
| (R)-N3-(2,6-Dimethoxy-4-methyl-5-(3-trifluoromethyl)phenoxy)quinolin-8-yl)pentane-1,4-diamine |
| 1,4-Pentanediamine,N4-(2,6-dimethoxy-4-methyl-5-(3-(trifluoromethyl)phenoxy)-8-quinolinyl) |
| Tafenoquine (USAN) |
| (RS)-N(sup 3)-(2,6-Dimethoxy-4-methyl-5-(3-trifluoro-methylphenoxy)quinolin-8-yl)pentane-1,4-diamine |