Mivacurium dichloride

Modify Date: 2024-01-05 21:16:36

Mivacurium dichloride structure	Common Name	Mivacurium dichloride
	CAS Number	106861-44-3	Molecular Weight	1100.17000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₅₈H₈₀Cl₂N₂O₁₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Mivacurium dichloride

Mivacurium dichloride is a benzylisoquinoline derivative and is a short-acting non-depolarizing neuromuscular blocking agent and skeletal muscle relaxant. Mivacurium dichloride couples with the nAChR to reduce or inhibit the depolarizing effect of acetylcholine on the terminal disc of the muscle cell[1][2][3].

Name	Mivacurium Chloride
Synonym	More Synonyms

Description	Mivacurium dichloride is a benzylisoquinoline derivative and is a short-acting non-depolarizing neuromuscular blocking agent and skeletal muscle relaxant. Mivacurium dichloride couples with the nAChR to reduce or inhibit the depolarizing effect of acetylcholine on the terminal disc of the muscle cell[1][2][3].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR Research Areas >> Neurological Disease
In Vitro	Mivacurium induces LAD2 cell degranulation in a dose-dependent manner. Mivacurium stimulates intracellular Ca2+ influx in MRGPRX2-HEK293 cells but not in NC-HEK293 cells. Mivacurium induces the release of only low levels of mediators in LAD2 cells transfected with MRGPRX2-targeted small interfering siRNA[1].
In Vivo	Mivacurium causes pseudo-allergic reactions in C57 wild-type mice by inducing mast cells to release histamine and a decrease in body temperature[1]. Mivacurium is rapidly hydrolyzed in the plasma and has a short duration of action (< 10 min). Mivacurium has many advantages, such as a rapid effect, nonneurological toxicity and a lack of heart rate alteration[1].
References	[1]. Delu Che, et al. Mivacurium Induce Mast Cell Activation and Pseudo-Allergic Reactions via MAS-related G Protein Coupled receptor-X2. Cell Immunol. 2018 Oct;332:121-128. [2]. Matthias Paul, et al. The Potency of New Muscle Relaxants on Recombinant Muscle-Type Acetylcholine Receptors. Anesth Analg. 2002 Mar;94(3):597-603; table of contents. [3]. J E Caldwell. New Skeletal Muscle Relaxants. Int Anesthesiol Clin. Winter 1995;33(1):39-60.

Molecular Formula	C₅₈H₈₀Cl₂N₂O₁₄
Molecular Weight	1100.17000
Exact Mass	1098.50000
PSA	144.90000
LogP	2.95460
Storage condition	-20℃

Mivacurium chloride

DC Chemicals Limited
China
Product Name: BW-B 1090U
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Mivacurium chloride
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Purity: 98.0%
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Zhejiang Hangyu API Co., Ltd
China
Product Name: mivacurium chloride
Price: ￥Inquiry/1kg
Purity: 99.5%
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Contact: Vinnie

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Mivacurium dichloride

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