Kazusamycin B
Modify Date: 2025-08-25 14:35:36
Kazusamycin B structure
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Common Name | Kazusamycin B | ||
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| CAS Number | 107140-30-7 | Molecular Weight | 542.70 | |
| Density | 1.118g/cm3 | Boiling Point | 754.2ºC at 760 mmHg | |
| Molecular Formula | C32H46O7 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 236.5ºC | |
Use of Kazusamycin BKazusamycin B is an antibiotic that could be isolated from the fermentation broth of Streptomyces sp. No. 81-484. Kazusamycin B inhibits cell growth and arrests cell cycle at G1 phase. Kazusamycin B can be used in research of cancer[1][2]. |
| Name | (2E,10E,12E,16Z,18E)-6-hydroxy-9-(hydroxymethyl)-3,5,7,11,15,17-hexamethyl-19-(3-methyl-6-oxo-2,3-dihydropyran-2-yl)-8-oxononadeca-2,10,12,16,18-pentaenoic acid |
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| Description | Kazusamycin B is an antibiotic that could be isolated from the fermentation broth of Streptomyces sp. No. 81-484. Kazusamycin B inhibits cell growth and arrests cell cycle at G1 phase. Kazusamycin B can be used in research of cancer[1][2]. |
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| Related Catalog | |
| In Vitro | Kazusamycin B (PD 124895; 5 ng/mL; 24 h; 1210 cells) 具有时间依赖性的细胞毒性，使细胞周期停滞在 G1 期[2]。 Kazusamycin B (5-50 ng/mL; 0-6 h; 1210 cells) 适度抑制 RNA 合成，但特异性抑制 2 小时[2]。 Cell Cycle Analysis[2] Cell Line: 1210 cells Concentration: 5 ng/mL Incubation Time: 24 h Result: Arrested cell cycle at G1 phase at 4 hours. |
| References |
| Density | 1.118g/cm3 |
|---|---|
| Boiling Point | 754.2ºC at 760 mmHg |
| Molecular Formula | C32H46O7 |
| Molecular Weight | 542.70 |
| Flash Point | 236.5ºC |
| Exact Mass | 542.32400 |
| PSA | 121.13000 |
| LogP | 5.36700 |
| Vapour Pressure | 2.96E-26mmHg at 25°C |
| Index of Refraction | 1.554 |
| InChIKey | OOQHBJFDAPXZJM-BBHORLQHSA-N |
| SMILES | CC(C=CC1OC(=O)C=CC1C)=CC(C)CC=CC(C)=CC(CO)C(=O)C(C)C(O)C(C)CC(C)=CC(=O)O |
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