PPC-NHS ester

Modify Date: 2024-01-10 12:02:15

PPC-NHS ester Structure
PPC-NHS ester structure
Common Name PPC-NHS ester
CAS Number 107348-47-0 Molecular Weight 327.39900
Density 1.43g/cm3 Boiling Point 468.8ºC at 760mmHg
Molecular Formula C13H14N2O4S2 Melting Point N/A
MSDS N/A Flash Point 237.3ºC

 Use of PPC-NHS ester


PPC-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

 Names

Name 3-[[1-(2,5-dioxopyrrolidin-1-yl)-2H-pyridin-2-yl]disulfanyl]butanoate
Synonym More Synonyms

 PPC-NHS ester Biological Activity

Description PPC-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
Related Catalog
Target

Cleavable

In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

 Chemical & Physical Properties

Density 1.43g/cm3
Boiling Point 468.8ºC at 760mmHg
Molecular Formula C13H14N2O4S2
Molecular Weight 327.39900
Flash Point 237.3ºC
Exact Mass 327.04700
PSA 131.35000
LogP 0.54770
Vapour Pressure 5.81E-09mmHg at 25°C
Index of Refraction 1.634
Storage condition -20°C

 Synonyms

MFCD28398150
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