Anwulignan
Modify Date: 2024-01-01 22:26:42
Anwulignan structure
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Common Name | Anwulignan | ||
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| CAS Number | 107534-93-0 | Molecular Weight | 328.402 | |
| Density | 1.159 | Boiling Point | 467.0±40.0 °C at 760 mmHg | |
| Molecular Formula | C20H24O4 | Melting Point | 70-71℃ | |
| MSDS | Chinese USA | Flash Point | 236℃ | |
Use of AnwulignanMacelignan(Anwuligan) is a natural compound isolated from Myristica fragrans Houtt; possesses therapeutic potentials against neurodegenerative diseases with oxidative stress and neuroinflammation.IC50 value:Target: in vitro: Macelignan significantly attenuated the ROS production and neurotoxicity induced by glutamate in HT22 cell [1]. At 24 h of biofilm growth, S. mutans, A. viscosus and S. sanguis biofilms were reduced by up to 30%, 30% and 38%, respectively, after treatment with 10 microg/mL macelignan for 5 min [2]. Cisplatin-induced phosphorylation of c-Jun N-terminal kinase1/2 (JNK1/2) and extracellular signal-regulated kinase1/2 (ERK1/2) was abrogated by pretreatment with macelignan, however, that of p38 was not significantly affected [3].in vivo: Macelignan attenuated the expression of phosphorylated c-Jun in cisplatin-treated mice [3]. Daily administration of macelignan reduced the spatial memory impairments induced by the chronic LPS infusions [4]. |
| Name | 4-[(2S,3R)-4-(1,3-benzodioxol-5-yl)-2,3-dimethylbutyl]-2-methoxyphenol |
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| Synonym | More Synonyms |
| Description | Macelignan(Anwuligan) is a natural compound isolated from Myristica fragrans Houtt; possesses therapeutic potentials against neurodegenerative diseases with oxidative stress and neuroinflammation.IC50 value:Target: in vitro: Macelignan significantly attenuated the ROS production and neurotoxicity induced by glutamate in HT22 cell [1]. At 24 h of biofilm growth, S. mutans, A. viscosus and S. sanguis biofilms were reduced by up to 30%, 30% and 38%, respectively, after treatment with 10 microg/mL macelignan for 5 min [2]. Cisplatin-induced phosphorylation of c-Jun N-terminal kinase1/2 (JNK1/2) and extracellular signal-regulated kinase1/2 (ERK1/2) was abrogated by pretreatment with macelignan, however, that of p38 was not significantly affected [3].in vivo: Macelignan attenuated the expression of phosphorylated c-Jun in cisplatin-treated mice [3]. Daily administration of macelignan reduced the spatial memory impairments induced by the chronic LPS infusions [4]. |
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| Related Catalog | |
| References |
| Density | 1.159 |
|---|---|
| Boiling Point | 467.0±40.0 °C at 760 mmHg |
| Melting Point | 70-71℃ |
| Molecular Formula | C20H24O4 |
| Molecular Weight | 328.402 |
| Flash Point | 236℃ |
| Exact Mass | 328.167450 |
| PSA | 47.92000 |
| LogP | 5.22 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.574 |
| Storage condition | -20°C |
| RIDADR | NONH for all modes of transport |
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| HS Code | 29329990 |
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Macelignan attenuates LPS-induced inflammation and reduces LPS-induced spatial learning impairments in rats.
Neurosci. Lett. 448(1) , 110-4, (2008) Previous studies have shown that macelignan has anti-inflammatory and neuroprotective effects. Subsequently, in the current study, we demonstrate that oral administrations of macelignan reduce the hip... |
| Phenol, 4-[(2S,3R)-4-(1,3-benzodioxol-5-yl)-2,3-dimethylbutyl]-2-methoxy- |
| HMS2219A18 |
| (+)-Anwulignan |
| Macelignan |
| 4-[(2S,3R)-4-(1,3-Benzodioxol-5-yl)-2,3-dimethylbutyl]-2-methoxyphenol |
| UNII-8PP3614Z43 |
| austrobailignan 6 |
| Anwuligan |
| Macelignan, (+)- |
- BioBioPha
- China
- Product Name: Anwulignan
- Price: ￥Inquiry/20mg
- Purity: 98.0%
- Stocking Period: 1 Day
- Contact: Xueping-Zheng
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Anwulignan
- Price: ￥1448.0/20mg
- Purity: 98.0%
- Stocking Period: 1 Day
- Contact: Liu jia
- DC Chemicals Limited
- China
- Product Name: Anwuligan
- Price: $280.0/20mg
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Zhejiang Hangyu API Co., Ltd
- China
- Product Name: Anwuligan
- Price: ￥Inquiry/1kg
- Purity: 99.5%
- Stocking Period: Inquiry
- Contact: Vinnie
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Price: $198/10mM*1mLinDMSO
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