Zamicastat

Modify Date: 2025-08-25 18:49:31

Zamicastat Structure
Zamicastat structure
 Common Name Zamicastat
CAS Number 1080028-80-3 Molecular Weight 401.47300
Density N/A Boiling Point N/A
Molecular Formula C21H21F2N3OS Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Zamicastat


Zamicastat is a concentration-dependent dual P-gp and BCRP inhibitor with IC50 values of 73.8±7.2 μM and 17.0±2.7 μM, respectively.

 Names

Name 4-[2-(benzylamino)ethyl]-3-[(3R)-6,8-difluoro-3,4-dihydro-2H-chromen-3-yl]-1H-imidazole-2-thione
Synonym More Synonyms

 Zamicastat Biological Activity

Description Zamicastat is a concentration-dependent dual P-gp and BCRP inhibitor with IC50 values of 73.8±7.2 μM and 17.0±2.7 μM, respectively.
Related Catalog
Target

IC50: 73.8±7.2 μM (P-gp), 17.0±2.7 μM (BCRP)[1]

In Vitro Zamicastat is a concentration-dependent dual P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) inhibitor with IC50 values of 73.8±7.2 μM and 17.0±2.7 μM. Zamicastat also reversibly inhibits dopamine β-hydroxylase (DBH) without effect in brain tissue[1].
References

[1]. Bicker J, et al. In vitro assessment of the interactions of dopamine β-hydroxylase inhibitors with human P-glycoprotein and Breast Cancer Resistance Protein. Eur J Pharm Sci. 2018 May 30;117:35-40.

 Chemical & Physical Properties

Molecular Formula C21H21F2N3OS
Molecular Weight 401.47300
Exact Mass 401.13700
PSA 77.88000
LogP 4.34940
Storage condition 2-8℃

 Synonyms

Zamitat
UNII-YLU32D0DNV
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Chemsrc provides Zamicastat(CAS#:1080028-80-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Zamicastat are included as well.>> amp version: Zamicastat

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