Antibacterial agent 122

Modify Date: 2024-01-18 16:47:27

Antibacterial agent 122 structure	Common Name	Antibacterial agent 122
	CAS Number	109310-99-8	Molecular Weight	302.35
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₅H₁₄N₂O₃S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Antibacterial agent 122

Antibacterial agent 122 (compound 15) is a thiourea derivative with anti-mycobacterial activity and low cytotoxicity. Antibacterial agent 122 can be used for tuberculosis-related studies[1].

Name	Antibacterial agent 122

Description	Antibacterial agent 122 (compound 15) is a thiourea derivative with anti-mycobacterial activity and low cytotoxicity. Antibacterial agent 122 can be used for tuberculosis-related studies[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Antibacterial agent 122 (compound 15) (25-200 µM, 24 h) inhibits M. tuberculosis H37Rv with the MIC50 value of 5.9 µM and inhibits NO production in LPS-stimulated RAW 264.7 cell cultures with an IC50 value of 8.1µM[1]. Antibacterial agent 122 (compound 15) (25-200 µM) acts on NO scavenging with an IC50 value of 184.2 µM, and almost completely inhibits iNOS expression in LPS-stimulated RAW264.7 macrophages at a concentration of 100 µM[1]. Antibacterial agent 122 (compound 15) (0-200 µM, 24 h) inhibits TNF-α and IL-1β production in LPS-stimulated macrophages with the IC50 values of 28.4 µM and 47.9 µM, respectively[1]. Antibacterial agent 122 (compound 15) (25-100 µM, 4 days) inhibits M. tuberculosis M299 with an MIC50 value of 24.7 µM[1].
References	[1]. Sanderson Dias Calixto, et al. Antimycobacterial and anti-inflammatory activities of thiourea derivatives focusing on treatment approaches for severe pulmonary tuberculosis. Bioorg Med Chem. 2022 Jan 1;53:116506.

Molecular Formula	C₁₅H₁₄N₂O₃S
Molecular Weight	302.35

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