Darifenacin-d4

Modify Date: 2024-01-12 18:46:18

Darifenacin-d4 structure	Common Name	Darifenacin-d4
	CAS Number	1095598-84-7	Molecular Weight	430.57
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₈H₂₆D₄N₂O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Darifenacin-d4

Darifenacin-d4 is the deuterium labeled Darifenacin[1]. Darifenacin(UK88525) is a selective M3 muscarinic receptor antagonist with pKi of 8.9. IC50 value: 8.9 (pKi)[2].

Name	Darifenacin-d4

Description	Darifenacin-d4 is the deuterium labeled Darifenacin[1]. Darifenacin(UK88525) is a selective M3 muscarinic receptor antagonist with pKi of 8.9. IC50 value: 8.9 (pKi)[2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> mAChR Signaling Pathways >> GPCR/G Protein >> mAChR
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Hegde SS, et al. Functional role of M2 and M3 muscarinic receptors in the urinary bladder of rats in vitro and in vivo. Br J Pharmacol, 1997, 120(8), 1409-1418.

Molecular Formula	C₂₈H₂₆D₄N₂O₂
Molecular Weight	430.57