NF 110
NF 110 structure
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Common Name | NF 110 | ||
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| CAS Number | 111150-22-2 | Molecular Weight | 1096.91000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C41H28N6Na4O17S4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of NF 110NF110 is a P2X3 receptor antagonist (Ki = 36 nM) and inactive toward P2Y receptors stably expressed (IC50s > 10 M). NF110 blocks alphabeta-methylene-ATP-induced currents (IC50 = 527 nM) in rat dorsal root ganglia neurons[1]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | NF 110,4,4',4'',4'''-[Carbonylbis[imino-5,1,3-benzenetriylbis(carbonylimino)]]tetrakisbenzenesulfonicacidtetrasodiumsalt |
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| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | NF110 is a P2X3 receptor antagonist (Ki = 36 nM) and inactive toward P2Y receptors stably expressed (IC50s > 10 M). NF110 blocks alphabeta-methylene-ATP-induced currents (IC50 = 527 nM) in rat dorsal root ganglia neurons[1]. |
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| Related Catalog | |
| Target |
Ki: 36 nM (P2X3 Receptor) |
| In Vitro | NF110 shows an activity in the human tumour cell line panel, with IC30 of 362.3 μM[2]. NF110 inhibits HMGA2-DNA interactions with an IC50 of 0.87 μM[3]. |
| In Vivo | NF110 shows potency at Endogenous P2X Receptors in Rat DRG Neurons, with a peak amplitude of 675 pA[1]. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Molecular Formula | C41H28N6Na4O17S4 |
|---|---|
| Molecular Weight | 1096.91000 |
| Exact Mass | 1096.00000 |
| PSA | 419.85000 |
| LogP | 8.71740 |
| InChIKey | AQJHZNCSXLBXMY-UHFFFAOYSA-J |
| SMILES | O=C(Nc1cc(C(=O)Nc2ccc(S(=O)(=O)[O-])cc2)cc(C(=O)Nc2ccc(S(=O)(=O)[O-])cc2)c1)Nc1cc(C(=O)Nc2ccc(S(=O)(=O)[O-])cc2)cc(C(=O)Nc2ccc(S(=O)(=O)[O-])cc2)c1.[Na+].[Na+].[Na+].[Na+] |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: Antagonist activity at human P2X3 receptor expressed in human 1321N1 cells assessed a...
Source: ChEMBL
Target: P2X purinoceptor 3
External Id: CHEMBL4479316
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| nf110 |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the English name of NF 110,4,4',4'',4'''-[Carbonylbis[imino-5,1,3-benzenetriylbis(carbonylimino)]]tetrakisbenzenesulfonicacidtetrasodiumsalt? |
| A: The English name of NF 110,4,4',4'',4'''-[Carbonylbis[imino-5,1,3-benzenetriylbis(carbonylimino)]]tetrakisbenzenesulfonicacidtetrasodiumsalt is NF 110,4,4',4'',4'''-[Carbonylbis[imino-5,1,3-benzenetriylbis(carbonylimino)]]tetrakisbenzenesulfonicacidtetrasodiumsalt. |
| Q: What is the molecular weight of NF 110,4,4',4'',4'''-[Carbonylbis[imino-5,1,3-benzenetriylbis(carbonylimino)]]tetrakisbenzenesulfonicacidtetrasodiumsalt? |
| A: Molecular weight of NF 110,4,4',4'',4'''-[Carbonylbis[imino-5,1,3-benzenetriylbis(carbonylimino)]]tetrakisbenzenesulfonicacidtetrasodiumsalt is 1096.91000. |
| Q: What is the polar surface area (PSA) of NF 110,4,4',4'',4'''-[Carbonylbis[imino-5,1,3-benzenetriylbis(carbonylimino)]]tetrakisbenzenesulfonicacidtetrasodiumsalt? |
| A: Polar surface area (PSA) of NF 110,4,4',4'',4'''-[Carbonylbis[imino-5,1,3-benzenetriylbis(carbonylimino)]]tetrakisbenzenesulfonicacidtetrasodiumsalt is 419.85000. |
| Q: What English synonyms does NF 110,4,4',4'',4'''-[Carbonylbis[imino-5,1,3-benzenetriylbis(carbonylimino)]]tetrakisbenzenesulfonicacidtetrasodiumsalt have? |
| A: English synonyms of NF 110,4,4',4'',4'''-[Carbonylbis[imino-5,1,3-benzenetriylbis(carbonylimino)]]tetrakisbenzenesulfonicacidtetrasodiumsalt: nf110. |
| Q: What is the CAS number of NF 110,4,4',4'',4'''-[Carbonylbis[imino-5,1,3-benzenetriylbis(carbonylimino)]]tetrakisbenzenesulfonicacidtetrasodiumsalt? |
| A: CAS number of NF 110,4,4',4'',4'''-[Carbonylbis[imino-5,1,3-benzenetriylbis(carbonylimino)]]tetrakisbenzenesulfonicacidtetrasodiumsalt is 111150-22-2. |
| Q: What is the SMILES notation of NF 110,4,4',4'',4'''-[Carbonylbis[imino-5,1,3-benzenetriylbis(carbonylimino)]]tetrakisbenzenesulfonicacidtetrasodiumsalt? |
| A: SMILES notation of NF 110,4,4',4'',4'''-[Carbonylbis[imino-5,1,3-benzenetriylbis(carbonylimino)]]tetrakisbenzenesulfonicacidtetrasodiumsalt is O=C(Nc1cc(C(=O)Nc2ccc(S(=O)(=O)[O-])cc2)cc(C(=O)Nc2ccc(S(=O)(=O)[O-])cc2)c1)Nc1cc(C(=O)Nc2ccc(S(=O)(=O)[O-])cc2)cc(C(=O)Nc2ccc(S(=O)(=O)[O-])cc2)c1.[Na+].[Na+].[Na+].[Na+]. |
| Q: What is the LogP of NF 110,4,4',4'',4'''-[Carbonylbis[imino-5,1,3-benzenetriylbis(carbonylimino)]]tetrakisbenzenesulfonicacidtetrasodiumsalt? |
| A: LogP of NF 110,4,4',4'',4'''-[Carbonylbis[imino-5,1,3-benzenetriylbis(carbonylimino)]]tetrakisbenzenesulfonicacidtetrasodiumsalt is 8.71740. |
| Q: What is the Chinese name of 111150-22-2? |
| A: Chinese name of 111150-22-2 is NF110. |
| Q: What are the uses of NF 110,4,4',4'',4'''-[Carbonylbis[imino-5,1,3-benzenetriylbis(carbonylimino)]]tetrakisbenzenesulfonicacidtetrasodiumsalt? |
| A: Main uses of NF 110,4,4',4'',4'''-[Carbonylbis[imino-5,1,3-benzenetriylbis(carbonylimino)]]tetrakisbenzenesulfonicacidtetrasodiumsalt: NF110 is a P2X3 receptor antagonist (Ki = 36 nM) and inactive toward P2Y receptors stably expressed (IC50s > 10 M). NF110 blocks alphabeta-methylene-ATP-induced currents (IC50 = 527 nM) in rat dorsal root ganglia neurons[1]. |
| Q: What is the molecular formula of NF 110,4,4',4'',4'''-[Carbonylbis[imino-5,1,3-benzenetriylbis(carbonylimino)]]tetrakisbenzenesulfonicacidtetrasodiumsalt? |
| A: Molecular formula of NF 110,4,4',4'',4'''-[Carbonylbis[imino-5,1,3-benzenetriylbis(carbonylimino)]]tetrakisbenzenesulfonicacidtetrasodiumsalt is C41H28N6Na4O17S4. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |