Sitravatinib (MGCD516)
Modify Date: 2025-08-28 16:51:31
Sitravatinib (MGCD516) structure
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Common Name | Sitravatinib (MGCD516) | ||
|---|---|---|---|---|
| CAS Number | 1123837-84-2 | Molecular Weight | 629.676 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 833.5±65.0 °C at 760 mmHg | |
| Molecular Formula | C33H29F2N5O4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 457.9±34.3 °C | |
Use of Sitravatinib (MGCD516)Sitravatinib is a novel small molecule inhibitor targeting multiple RTKs involved in driving sarcoma cell growth with IC50 of 3980 nmol/Lin vitro: MGCD516 is superior to other multi-kinase inhibitors in inhibiting cell proliferation, RTK phosphorylation, and phosphorylation of downstream effectors. MGCD516 is unique in a way that it has broad spectrum activity against many RTKs including c-Met, c-Kit, Axl, PDGFR, and Eph receptors that are known to play a role in driving sarcoma cell growthIn vivo: MGCD516 induces significant tumor growth suppression than imatinib and crizotinib. |
| Name | Sitravatinib |
|---|---|
| Synonym | More Synonyms |
| Description | Sitravatinib is a novel small molecule inhibitor targeting multiple RTKs involved in driving sarcoma cell growth with IC50 of 3980 nmol/Lin vitro: MGCD516 is superior to other multi-kinase inhibitors in inhibiting cell proliferation, RTK phosphorylation, and phosphorylation of downstream effectors. MGCD516 is unique in a way that it has broad spectrum activity against many RTKs including c-Met, c-Kit, Axl, PDGFR, and Eph receptors that are known to play a role in driving sarcoma cell growthIn vivo: MGCD516 induces significant tumor growth suppression than imatinib and crizotinib. |
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| Related Catalog | |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 833.5±65.0 °C at 760 mmHg |
| Molecular Formula | C33H29F2N5O4S |
| Molecular Weight | 629.676 |
| Flash Point | 457.9±34.3 °C |
| Exact Mass | 629.190857 |
| LogP | 6.00 |
| Vapour Pressure | 0.0±3.1 mmHg at 25°C |
| Index of Refraction | 1.685 |
| Storage condition | -20℃ |
| UNII:CWG62Q1VTB |
| CWG62Q1VTB |
| MGCD516 |
| Sitravatinib |
| 1,1-Cyclopropanedicarboxamide, N-[3-fluoro-4-[[2-[5-[[(2-methoxyethyl)amino]methyl]-2-pyridinyl]thieno[3,2-b]pyridin-7-yl]oxy]phenyl]-N'-(4-fluorophenyl)- |
| N-(3-Fluoro-4-{[2-(5-{[(2-methoxyethyl)amino]methyl}-2-pyridinyl)thieno[3,2-b]pyridin-7-yl]oxy}phenyl)-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide |