Lurasidone-d8

Modify Date: 2024-01-16 12:25:50

Lurasidone-d8 structure	Common Name	Lurasidone-d8
	CAS Number	1132654-54-6	Molecular Weight	500.73
	Density	1.3±0.1 g/cm3	Boiling Point	623.4±55.0 °C at 760 mmHg
	Molecular Formula	C₂₈H₂₈D₈N₄O₂S	Melting Point	259-261°C (dec.)
	MSDS	N/A	Flash Point	330.8±31.5 °C

Use of Lurasidone-d8

Lurasidone-d8 is deuterium labeled Lurasidone. Lurasidone (SM-13496) is an antagonist of both dopamine D2 and 5-HT7 with IC50s of 1.68 and 0.495 nM, respectively. Lurasidone (SM-13496) is also a partial agonist of 5-HT1A receptor with an IC50 of 6.75 nM.

Name	Lurasidone-d8 Hydrochloride
Synonym	More Synonyms

Description	Lurasidone-d8 is deuterium labeled Lurasidone. Lurasidone (SM-13496) is an antagonist of both dopamine D2 and 5-HT7 with IC50s of 1.68 and 0.495 nM, respectively. Lurasidone (SM-13496) is also a partial agonist of 5-HT1A receptor with an IC50 of 6.75 nM.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Ishibashi T, et al. Pharmacological profile of lurasidone, a novel antipsychotic agent with potent 5-hydroxytryptamine 7 (5-HT7) and 5-HT1A receptor activity. J Pharmacol Exp Ther. 2010 Jul;334(1):171-81. [3]. Sakine Atila Karaca, et al. Development of a validated high-performance liquid chromatographic method for the determination of Lurasidone in pharmaceuticals. Marmara Pharm J. 2017;21 (4): 931-937.

Density	1.3±0.1 g/cm3
Boiling Point	623.4±55.0 °C at 760 mmHg
Melting Point	259-261°C (dec.)
Molecular Formula	C₂₈H₂₈D₈N₄O₂S
Molecular Weight	500.73
Flash Point	330.8±31.5 °C
Exact Mass	500.306122
LogP	4.52
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.637
Storage condition	Refrigerator

4,7-Methano-1H-isoindole-1,3(2H)-dione, 2-[[(1R,2R)-2-[[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl-2,2,3,3,5,5,6,6-d8]methyl]cyclohexyl]methyl]hexahydro-, (3aR,4S,7R,7aS)-

(1R,2S,6R,7S)-4-{[(1R,2R)-2-{[4-(1,2-Benzothiazol-3-yl)(2H8)-1-piperazinyl]methyl}cyclohexyl]methyl}-4-azatricyclo[5.2.1.02,6]decane-3,5-dione

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Lurasidone-d8
Price: Negotiable
Purity: 99.0%
Delivery: 10 Day
Contact: Huang
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