Neuropeptide Y (18-36) trifluoroacetate salt

Modify Date: 2024-01-13 19:19:11

Neuropeptide Y (18-36) trifluoroacetate salt Structure
Neuropeptide Y (18-36) trifluoroacetate salt structure
Common Name Neuropeptide Y (18-36) trifluoroacetate salt
CAS Number 114495-97-5 Molecular Weight 2456.80000
Density N/A Boiling Point N/A
Molecular Formula C112H174N36O27 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Neuropeptide Y (18-36) trifluoroacetate salt


Neuropeptide Y (18-36) (porcine) is a competitive neuropeptide Y (NPY) cardiac receptor antagonist. Neuropeptide Y (18-36) (porcine) inhibits the binding of I-NPY to rat cardiac ventricular membranes in a concentration-dependent manner with an IC50 value of 158 nM and an Ki value of 140 nM. Neuropeptide Y (18-36) (porcine) can be used for the research of congestive heart failure[1].

 Names

Name Neuropeptide Y (18-36), porcine

  Biological Activity

Description Neuropeptide Y (18-36) (porcine) is a competitive neuropeptide Y (NPY) cardiac receptor antagonist. Neuropeptide Y (18-36) (porcine) inhibits the binding of I-NPY to rat cardiac ventricular membranes in a concentration-dependent manner with an IC50 value of 158 nM and an Ki value of 140 nM. Neuropeptide Y (18-36) (porcine) can be used for the research of congestive heart failure[1].
Related Catalog
Target

IC50: 158 nM (I-NPY); Ki: 140 nM (I-NPY)[1]

In Vitro Neuropeptide Y (18-36) (porcine) inhibits the binding of I-NPY to rat cardiac ventricular membranes in a concentration-dependent manner with an IC50 value of 158 nM and an Ki value of 140 nM[1]. Neuropeptide Y (18-36) (porcine) (1 μM) shifts the inhibitory adenylate cyclase activity dose-response curve of NPY to the right in a parallel fashion[1]. Neuropeptide Y (18-36) (porcine) (1 μM) completely abolishes the effect of NPY (10 nM) that alone caused 80% of the maximum inhibition of adenylate cyclase activity[1].
References

[1]. A Balasubramaniam, et al. Neuropeptide Y (18-36) is a competitive antagonist of neuropeptide Y in rat cardiac ventricular membranes. J Biol Chem. 1990 Sep 5;265(25):14724-7.

 Chemical & Physical Properties

Molecular Formula C112H174N36O27
Molecular Weight 2456.80000
Exact Mass 2455.33000
PSA 1076.75000
LogP 5.67680