CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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AJ1476901
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CHEMICAL NAME :
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Acetic acid, oxo-((3-(1H-tetrazol-5-yl)phenyl)amino)-
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CAS REGISTRY NUMBER :
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114607-46-4
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LAST UPDATED :
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199512
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DATA ITEMS CITED :
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5
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MOLECULAR FORMULA :
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C9-H7-N5-O3
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MOLECULAR WEIGHT :
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233.21
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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>4 gm/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 49,111,1995
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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1927 mg/kg
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TOXIC EFFECTS :
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Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory depression Blood - normocytic anemia
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REFERENCE :
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OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 49,111,1995
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TYPE OF TEST :
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LD - Lethal dose
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Mammal - dog
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DOSE/DURATION :
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>1500 mg/kg
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TOXIC EFFECTS :
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Behavioral - somnolence (general depressed activity) Cardiac - arrhythmias (including changes in conduction) Gastrointestinal - nausea or vomiting
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REFERENCE :
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OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 49,231,1995 ** OTHER MULTIPLE DOSE TOXICITY DATA **
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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22680 mg/kg/28D-C
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TOXIC EFFECTS :
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Liver - changes in liver weight Blood - changes in platelet count Related to Chronic Data - death
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REFERENCE :
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KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 23,107,1989
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Mammal - dog
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DOSE/DURATION :
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28 gm/kg/4W-I
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TOXIC EFFECTS :
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Kidney, Ureter, Bladder - urine volume increased Kidney, Ureter, Bladder - other changes in urine composition Blood - normocytic anemia
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REFERENCE :
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OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 49,235,1995
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