INDY
Modify Date: 2024-01-09 17:51:22
INDY structure
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Common Name | INDY | ||
|---|---|---|---|---|
| CAS Number | 1169755-45-6 | Molecular Weight | 235.30200 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C12H13NO2S | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
Use of INDYINDY is a potent and ATP-competitive Dyrk1A and Dyrk1B inhibitor with IC50s of 0.24 μM and 0.23 μM, respectively. INDY binds in the ATP pocket of the enzyme and has a Ki value of 0.18 μM for Dyrk1A. INDY sharply reduces the self-renewal capacity of normal and tumorigenic cells in primary Glioblastoma (GBM) cell lines and neural progenitor cells[1][2]. |
| Name | (Z)-1-(3-ethyl-5-hydroxybenzo[d]thiazol-2(3H)-ylidene)propan-2-one |
|---|---|
| Synonym | More Synonyms |
| Description | INDY is a potent and ATP-competitive Dyrk1A and Dyrk1B inhibitor with IC50s of 0.24 μM and 0.23 μM, respectively. INDY binds in the ATP pocket of the enzyme and has a Ki value of 0.18 μM for Dyrk1A. INDY sharply reduces the self-renewal capacity of normal and tumorigenic cells in primary Glioblastoma (GBM) cell lines and neural progenitor cells[1][2]. |
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| Related Catalog | |
| Target |
IC50: 0.24 μM (Dyrk1A) and 0.23 μM (Dyrk1B)[1] Ki: 0.18 μM (Dyrk1A)[1] |
| In Vitro | INDY (0.3-30 μM; 20 hours) mildly inhibits tau-phosphorylation at 3 μM, and nearly completely inhibits at 30 μM[1]. INDY effectively reverses the aberrant tau-phosphorylation and rescues the repressed NFAT (nuclear factor of activated T cell) signalling induced by Dyrk1A (dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 1A) overexpression[1]. Western Blot Analysis[1] Cell Line: COS7 cells transfected with either EGFP-Dyrk1A and EGFP-tau Concentration: 0.3, 1, 3, 10, 30 μM Incubation Time: 20 hours Result: Mildly inhibited tau-phosphorylation at 3 μM, and nearly completely inhibited at 30 μM. |
| In Vivo | ProINDY (2.5 μM) recoveres apparently normal development of the Xenopus embryo[1]. |
| References |
| Molecular Formula | C12H13NO2S |
|---|---|
| Molecular Weight | 235.30200 |
| Exact Mass | 235.06700 |
| PSA | 70.47000 |
| LogP | 2.07890 |
| Storage condition | -20°C |
| RIDADR | NONH for all modes of transport |
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| Phencyclidine hydrochloride |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: INDY
- Price: Negotiable
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: INDY
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
- DC Chemicals Limited
- China
- Product Name: INDY
- Price: $700.0/100mg $1400.0/250mg $2800.0/1g
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
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