PF0346275
Modify Date: 2025-08-24 22:27:07
PF0346275 structure
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Common Name | PF0346275 | ||
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| CAS Number | 1173239-39-8 | Molecular Weight | 449.777 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H22ClFN4O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PF0346275A potent, selective, orally available GlyT1 inhibitor with Ki of 11.6 nM, without activity against GlyT2 (IC50>10 uM); demonstrates potent activity in elevating CSF levels of glycine in vivo (ED200, 3.5 mg/kg). |
| Name | N-(3-Chloro-4-fluorobenzyl)-1-methyl-N-{[(1R,5S,6r)-3-methyl-3-azabicyclo[3.1.0]hex-6-yl]methyl}-1H-imidazole-4-carboxamide dihydrochloride |
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| Synonym | More Synonyms |
| Description | A potent, selective, orally available GlyT1 inhibitor with Ki of 11.6 nM, without activity against GlyT2 (IC50>10 uM); demonstrates potent activity in elevating CSF levels of glycine in vivo (ED200, 3.5 mg/kg). |
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| References | References 1. Lowe JA 3rd, et al. Bioorg Med Chem Lett. 2009 Jun 1;19(11):2974-6. 2. Yamamoto S, et al. Chem Pharm Bull (Tokyo). 2016;64(11):1630-1640. View Related Products by Target Glycine Transporter (GlyT) |
| Molecular Formula | C19H22ClFN4O |
|---|---|
| Molecular Weight | 449.777 |
| Exact Mass | 448.099976 |
| N-(3-Chloro-4-fluorobenzyl)-1-methyl-N-{[(1R,5S,6r)-3-methyl-3-azabicyclo[3.1.0]hex-6-yl]methyl}-1H-imidazole-4-carboxamide dihydrochloride |
| 1H-Imidazole-4-carboxamide, N-[(3-chloro-4-fluorophenyl)methyl]-1-methyl-N-[[(1R,5S)-3-methyl-3-azabicyclo[3.1.0]hex-6-yl]methyl]-, hydrochloride (1:2) |