3'-azido-3'-deoxy-5'-O-beta-glucopyranuronosylthymidine

Modify Date: 2025-10-01 12:39:10

3'-azido-3'-deoxy-5'-O-beta-glucopyranuronosylthymidine structure	Common Name	3'-azido-3'-deoxy-5'-O-beta-glucopyranuronosylthymidine
	CAS Number	117675-21-5	Molecular Weight	443.37
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₆H₂₁N₅O₁₀	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of 3'-azido-3'-deoxy-5'-O-beta-glucopyranuronosylthymidine

Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) sodium is the major metabolite of Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection[1][2].

Name	(2S,3S,4S,5R)-6-[[(2S)-3-azido-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy]-3,4,5-trihydroxyoxane-2-carboxylic acid
Synonym	More Synonyms

Description	Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) sodium is the major metabolite of Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection[1][2].
Related Catalog	Research Areas >> Others
References	[1]. Fayz S, et, al. Zidovudine azido-reductase in human liver microsomes: activation by ethacrynic acid, dipyridamole, and indomethacin and inhibition by human immunodeficiency virus protease inhibitors. Antimicrob Agents Chemother. 1998 Jul;42(7):1654-8. [2]. Bélanger AS, et, al. Glucuronidation of the antiretroviral drug efavirenz by UGT2B7 and an in vitro investigation of drug-drug interaction with zidovudine. Drug Metab Dispos. 2009 Sep;37(9):1793-6.

Description

Related Catalog

Research Areas >> Others

References

[1]. Fayz S, et, al. Zidovudine azido-reductase in human liver microsomes: activation by ethacrynic acid, dipyridamole, and indomethacin and inhibition by human immunodeficiency virus protease inhibitors. Antimicrob Agents Chemother. 1998 Jul;42(7):1654-8.

[2]. Bélanger AS, et, al. Glucuronidation of the antiretroviral drug efavirenz by UGT2B7 and an in vitro investigation of drug-drug interaction with zidovudine. Drug Metab Dispos. 2009 Sep;37(9):1793-6.