Tazarotenic Acid

Modify Date: 2024-01-13 13:42:53

Tazarotenic Acid structure	Common Name	Tazarotenic Acid
	CAS Number	118292-41-4	Molecular Weight	323.409
	Density	1.3±0.1 g/cm3	Boiling Point	527.5±50.0 °C at 760 mmHg
	Molecular Formula	C₁₉H₁₇NO₂S	Melting Point	N/A
	MSDS	N/A	Flash Point	272.9±30.1 °C

Use of Tazarotenic Acid

Tazarotenic acid is the metabolite of Tazarotene. Tazarotenic acid binding to retinoic acid receptors (RARs) is the probable molecular target of retinoid action. Tazarotenic acid has the potential for the research of warty dyskeratoma[1][2][3].

Name	tazarotenic acid
Synonym	More Synonyms

Description	Tazarotenic acid is the metabolite of Tazarotene. Tazarotenic acid binding to retinoic acid receptors (RARs) is the probable molecular target of retinoid action. Tazarotenic acid has the potential for the research of warty dyskeratoma[1][2][3].
Related Catalog	Research Areas >> Others
In Vivo	Assessment of Pharmacokinetics (PK) profile of Tazarotenic acid (Compound AGN 190299) after an intravenous of AGN 190168 in rats[1] . Male Female Male Dose (mg kg-1) 4.4 4.4 0.49 AUC (μg h mL-1) 9.31 (2.14) 9.78 (1.36) 0.594 (0.95) CL (mL min-1 kg-1) 7.96 (1.59) 7.62 (0.85) 14.0 (2.2) k (h-1) 0.562 (0.339) 0.820 (0.146) 0.741 (0.115) T1/2 (h) 1.64 (0.92) 0.86 (0.14) 0.95 (0.16) V0 (L kg-1) 0.43 (0.05) 0.49 (0.06) 1.31 (1.15) Vβ (L kg-1) - - 1.14 (0.09) Vmax (μg min-1) 9.08 (2.89) 6.09 (1.22) - Km (μg mL-1) 7.09 (1.35) 5.12 (1.19) -
References	[1]. Chandraratna RA. Tazarotene--first of a new generation of receptor-selective retinoids. Br J Dermatol. 1996;135 Suppl 49:18-25. [2]. Hsyu PH, et al. Pharmacokinetics of a novel retinoid AGN 190168 and its metabolite AGN 190299 after intravenous administration of AGN 190168 to rats. Biopharm Drug Dispos. 1994;15(5):347-357. [3]. Abramovits W, et al. Treatment of warty dyskeratoma with tazarotenic acid. J Am Acad Dermatol. 2002;46(2 Suppl Case Reports):S4.

Density	1.3±0.1 g/cm3
Boiling Point	527.5±50.0 °C at 760 mmHg
Molecular Formula	C₁₉H₁₇NO₂S
Molecular Weight	323.409
Flash Point	272.9±30.1 °C
Exact Mass	323.097992
PSA	75.49000
LogP	4.95
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.671
Storage condition	2-8°C

N/A

CAS#:952294-17-6

Tazarotenic Acid

CAS#:118292-41-4

Literature: US2007/238881 A1, ; Page/Page column 6 ;

Precursor 0
DownStream 1
CAS#:118292-40-3 Tazarotene

Tazarotenic Acid

3-Pyridinecarboxylic acid, 6-[2-(3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl]-

6-[2-(4,4-dimethyl-2,3-dihydrothiochromen-6-yl)ethynyl]pyridine-3-carboxylic acid

6-[(4,4-Dimethyl-3,4-dihydro-2H-thiochromen-6-yl)ethynyl]nicotinic acid

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Tazarotenicacid
Price: Negotiable
Purity: 98.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: Tazarotenic acid (AGN 190299)
Price: $325.0/100mg $650.0/250mg $1300.0/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: Tazarotenic acid (AGN 190299)
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 6-(4,4-DIMETHYL-THIOCHROMAN-6-YLETHYNYL)-NICOTINIC ACID
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Get all suppliers and price by the below link:

Tazarotenic Acid suppliers

Price: ￥1800/5 mg

Reference only. check more Tazarotenic Acid price

Tazarotenic Acid

Use of Tazarotenic Acid

Names

Tazarotenic Acid Biological Activity

Chemical & Physical Properties

Synthetic Route

Precursor & DownStream

Synonyms