MTIC-d3
Modify Date: 2024-02-03 21:48:22
MTIC-d3 structure
|
Common Name | MTIC-d3 | ||
|---|---|---|---|---|
| CAS Number | 1185242-69-6 | Molecular Weight | 171.18 | |
| Density | 1.7±0.1 g/cm3 | Boiling Point | 486.3±55.0 °C at 760 mmHg | |
| Molecular Formula | C5H5D3N6O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 247.9±31.5 °C | |
Use of MTIC-d3MTIC-d3 is deuterium labeled MTIC. MTIC is the active metabolite of Temozolomide (TMZ). MITC has lower bioavailability in the brain compared with TMZ, because the drug’s permeability through biological barriers and tumor cell membranes affects bioavailability. MITC exhibits low affinity to biological membrane[1]. |
| Name | 4-[(1E)-3-(2H3)Methyl-1-triazen-1-yl]-1H-imidazole-5-carboxamide |
|---|---|
| Synonym | More Synonyms |
| Description | MTIC-d3 is deuterium labeled MTIC. MTIC is the active metabolite of Temozolomide (TMZ). MITC has lower bioavailability in the brain compared with TMZ, because the drug’s permeability through biological barriers and tumor cell membranes affects bioavailability. MITC exhibits low affinity to biological membrane[1]. |
|---|---|
| Related Catalog | |
| In Vitro | Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1]. |
| References |
| Density | 1.7±0.1 g/cm3 |
|---|---|
| Boiling Point | 486.3±55.0 °C at 760 mmHg |
| Molecular Formula | C5H5D3N6O |
| Molecular Weight | 171.18 |
| Flash Point | 247.9±31.5 °C |
| Exact Mass | 171.094788 |
| LogP | 0.17 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.741 |
| 4-[(1E)-3-(2H3)Methyl-1-triazen-1-yl]-1H-imidazole-5-carboxamide |
| 1H-Imidazole-4-carboxamide, 5-[(1E)-3-(methyl-d3)-1-triazen-1-yl]- |