Tocrifluor T1117

Modify Date: 2024-01-13 15:06:23

Tocrifluor T1117 Structure
Tocrifluor T1117 structure
Common Name Tocrifluor T1117
CAS Number 1186195-59-4 Molecular Weight 974.970
Density 1.3±0.1 g/cm3 Boiling Point N/A
Molecular Formula C56H53Cl2N7O5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Tocrifluor T1117


Tocrifluor 1117 (T1117), a fluorescent form of the cannabinoid CB1 receptor antagonist AM251, is a selective fluorescent GPR55 ligand. Tocrifluor 1117 is a potent tool for identifying the cellular location of cannabinoid receptors (including GPR55 in living tissues) (Ex/Em=543/590 nm)[1][2].

 Names

Name T1117
Synonym More Synonyms

 Tocrifluor T1117 Biological Activity

Description Tocrifluor 1117 (T1117), a fluorescent form of the cannabinoid CB1 receptor antagonist AM251, is a selective fluorescent GPR55 ligand. Tocrifluor 1117 is a potent tool for identifying the cellular location of cannabinoid receptors (including GPR55 in living tissues) (Ex/Em=543/590 nm)[1][2].
Related Catalog
Target

CB1

References

[1]. Daly CJ, et al. Fluorescent ligand binding reveals heterogeneous distribution of adrenoceptors and 'cannabinoid-like' receptors in small arteries. Br J Pharmacol. 2010 Feb;159(4):787-96.

[2]. Singh NS, et al. Selective GPR55 antagonism reduces chemoresistance in cancer cells. Pharmacol Res. 2016 Sep;111:757-766.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Molecular Formula C56H53Cl2N7O5
Molecular Weight 974.970
Exact Mass 973.348511
LogP 10.77
Index of Refraction 1.678

 Synonyms

1H-Pyrazole-3-carboxamide, 5-[4'-[3-[[[3',6'-bis(dimethylamino)-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-5-yl]carbonyl]amino]propyl][1,1'-biphenyl]-4-yl]-1-(2,4-dichlorophenyl)-4-methyl-N-1-piperidinyl-
5-{4'-[3-({[3',6'-Bis(dimethylamino)-3-oxo-3H-spiro[2-benzofuran-1,9'-xanthen]-5-yl]carbonyl}amino)propyl]biphenyl-4-yl}-1-(2,4-dichlorophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide
T1117
5-{4'-[3-({[3',6'-Bis(dimethylamino)-3-oxo-3H-spiro[2-benzofuran-1,9'-xanthen]-5-yl]carbonyl}amino)propyl]-4-biphenylyl}-1-(2,4-dichlorophenyl)-4-methyl-N-(1-piperidinyl)-1H-pyrazole-3-carboxamide
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