Becatecarin

Modify Date: 2024-01-10 21:09:03

Becatecarin structure	Common Name	Becatecarin
	CAS Number	119673-08-4	Molecular Weight	669.552
	Density	1.6±0.1 g/cm3	Boiling Point	848.8±65.0 °C at 760 mmHg
	Molecular Formula	C₃₃H₃₄Cl₂N₄O₇	Melting Point	N/A
	MSDS	N/A	Flash Point	467.2±34.3 °C

Use of Becatecarin

Becatecarin is a rebeccamycin analog with antitumor effects. Becatecarin intercalates into DNA and inhibites the catalytic activity of topoisomerases I/II.

Name	Becatecarin
Synonym	More Synonyms

Description	Becatecarin is a rebeccamycin analog with antitumor effects. Becatecarin intercalates into DNA and inhibites the catalytic activity of topoisomerases I/II.
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase
References	[1]. Long BH, Rose WC, Vyas DM, Matson JA, Forenza S. Discovery of antitumor indolocarbazoles: rebeccamycin, NSC 655649, and fluoroindolocarbazoles. Curr Med Chem Anticancer Agents. 2002;2(2):255-266. [2]. Robey RW, Obrzut T, Shukla S, et al. Becatecarin (rebeccamycin analog, NSC 655649) is a transport substrate and induces expression of the ATP-binding cassette transporter, ABCG2, in lung carcinoma cells. Cancer Chemother Pharmacol. 2009;64(3):575-583.

Description

Becatecarin is a rebeccamycin analog with antitumor effects. Becatecarin intercalates into DNA and inhibites the catalytic activity of topoisomerases I/II.

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase

References

[1]. Long BH, Rose WC, Vyas DM, Matson JA, Forenza S. Discovery of antitumor indolocarbazoles: rebeccamycin, NSC 655649, and fluoroindolocarbazoles. Curr Med Chem Anticancer Agents. 2002;2(2):255-266.

[2]. Robey RW, Obrzut T, Shukla S, et al. Becatecarin (rebeccamycin analog, NSC 655649) is a transport substrate and induces expression of the ATP-binding cassette transporter, ABCG2, in lung carcinoma cells. Cancer Chemother Pharmacol. 2009;64(3):575-583.

Density	1.6±0.1 g/cm3
Boiling Point	848.8±65.0 °C at 760 mmHg
Molecular Formula	C₃₃H₃₄Cl₂N₄O₇
Molecular Weight	669.552
Flash Point	467.2±34.3 °C
Exact Mass	668.180481
PSA	142.18000
LogP	7.17
Vapour Pressure	0.0±3.3 mmHg at 25°C
Index of Refraction	1.739

5H-Indolo(2,3-a)pyrrolo(3,4-c)carbazole-5,7(6H)-dione, 1,11-dichloro-6-(2-(diethylamino)ethyl)-12,13-dihydro-12-(4-O-methyl-β-D-glucopyranosyl)-

Becatecarin

1,11-Dichloro-6-(2-(diethylamino)ethyl)-12,13-dihydro-12-(4-O-methyl-β-D-glucopyranosyl)-5H-indolo(2,3-a)pyrrolo(3,4-c)carbazole-5,7(6H)-dione

1,11-Dichloro-6-[2-(diethylamino)ethyl]-12-(4-O-methyl-β-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione

5H-Indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione, 1,11-dichloro-6-[2-(diethylamino)ethyl]-12,13-dihydro-12-(4-O-methyl-β-D-glucopyranosyl)-

1,11-dichloro-6-(2-(diethylamino)ethyl)-12-((2R,3R,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-2-yl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione

DC Chemicals Limited
China
Product Name: BMS-181176
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Purity: 98.0%
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