SRTCX1002
Modify Date: 2024-10-11 21:23:26
SRTCX1002 structure
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Common Name | SRTCX1002 | ||
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| CAS Number | 1203479-63-3 | Molecular Weight | 405.473 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C21H19N5O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SRTCX1002SRTCX1002 (SRTCX-1002) is a small molecule activator of SIRT1 (STAC) with EC1.5 of 0.4 uM, enhances deacetylation of cellular p65 protein with IC50 of 0.84 uM in cellular p65 acetylation assay; suppresses TNFα-induced NF-κB transcriptional activation and reduction of LPS-stimulated TNFα secretion in a SIRT1-dependent manner. |
| Name | 2-[3-(4-Morpholinyl)phenyl]-N-(1,3-thiazol-2-yl)-1H-benzimidazole-4-carboxamide |
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| Synonym | More Synonyms |
| Description | SRTCX1002 (SRTCX-1002) is a small molecule activator of SIRT1 (STAC) with EC1.5 of 0.4 uM, enhances deacetylation of cellular p65 protein with IC50 of 0.84 uM in cellular p65 acetylation assay; suppresses TNFα-induced NF-κB transcriptional activation and reduction of LPS-stimulated TNFα secretion in a SIRT1-dependent manner. |
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| References | References 1. Yang H, et al. PLoS One. 2012;7(9):e46364. 2. Kim SY, et al. PLoS One. 2015 Jul 15;10(7):e0133448. View Related Products by Target Sirtuin |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Molecular Formula | C21H19N5O2S |
| Molecular Weight | 405.473 |
| Exact Mass | 405.125946 |
| LogP | 2.73 |
| Index of Refraction | 1.732 |
| 1H-Benzimidazole-7-carboxamide, 2-[3-(4-morpholinyl)phenyl]-N-2-thiazolyl- |
| 2-[3-(4-Morpholinyl)phenyl]-N-(1,3-thiazol-2-yl)-1H-benzimidazole-4-carboxamide |