Ketone Ester
Modify Date: 2024-01-02 15:37:58
Ketone Ester structure
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Common Name | Ketone Ester | ||
|---|---|---|---|---|
| CAS Number | 1208313-97-6 | Molecular Weight | 176.21000 | |
| Density | 1.102 | Boiling Point | 269 ºC | |
| Molecular Formula | C8H16O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 101 ºC | |
Use of Ketone EsterBD-AcAc 2, added in diet, could elevated mean blood ketone bodies of 3.5 mm and lowered plasma glucose, insulin, and leptin in animals; ketone ester given orally would delay CNS-OT seizures in rats breathing hyperbaric oxygen.IC50 value:Target:a ketone ester given orally as R,S-1,3-butanediol acetoacetate diester (BD-AcAc(2)) would delay CNS-OT seizures in rats breathing hyperbaric oxygen (HBO(2)). Adult male rats (n = 60) were implanted with radiotelemetry units to measure electroencephalogram (EEG). One week postsurgery, rats were administered a single oral dose of BD-AcAc(2), 1,3-butanediol (BD), or water 30 min before being placed into a hyperbaric chamber and pressurized to 5 atmospheres absolute (ATA) O2 [1]. Beginning at a presymptomatic age, 2 groups of male 3xTgAD mice were fed a diet containing a physiological enantiomeric precursor of ketone bodies (KET) or an isocaloric carbohydrate diet. The results of behavioral tests performed at 4 and 7 months after diet initiation revealed that KET-fed mice exhibited significantly less anxiety in 2 different tests. 3xTgAD mice on the KET diet also exhibited significant, albeit relatively subtle, improvements in performance on learning and memory tests. Immunohistochemical analyses revealed that KET-fed mice exhibited decreased Aβ deposition in the subiculum, CA1 and CA3 regions of the hippocampus, and the amygdala [2]. |
| Name | [(3R)-3-hydroxybutyl] (3R)-3-hydroxybutanoate |
|---|---|
| Synonym | More Synonyms |
| Description | BD-AcAc 2, added in diet, could elevated mean blood ketone bodies of 3.5 mm and lowered plasma glucose, insulin, and leptin in animals; ketone ester given orally would delay CNS-OT seizures in rats breathing hyperbaric oxygen.IC50 value:Target:a ketone ester given orally as R,S-1,3-butanediol acetoacetate diester (BD-AcAc(2)) would delay CNS-OT seizures in rats breathing hyperbaric oxygen (HBO(2)). Adult male rats (n = 60) were implanted with radiotelemetry units to measure electroencephalogram (EEG). One week postsurgery, rats were administered a single oral dose of BD-AcAc(2), 1,3-butanediol (BD), or water 30 min before being placed into a hyperbaric chamber and pressurized to 5 atmospheres absolute (ATA) O2 [1]. Beginning at a presymptomatic age, 2 groups of male 3xTgAD mice were fed a diet containing a physiological enantiomeric precursor of ketone bodies (KET) or an isocaloric carbohydrate diet. The results of behavioral tests performed at 4 and 7 months after diet initiation revealed that KET-fed mice exhibited significantly less anxiety in 2 different tests. 3xTgAD mice on the KET diet also exhibited significant, albeit relatively subtle, improvements in performance on learning and memory tests. Immunohistochemical analyses revealed that KET-fed mice exhibited decreased Aβ deposition in the subiculum, CA1 and CA3 regions of the hippocampus, and the amygdala [2]. |
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| Related Catalog | |
| References |
| Density | 1.102 |
|---|---|
| Boiling Point | 269 ºC |
| Molecular Formula | C8H16O4 |
| Molecular Weight | 176.21000 |
| Flash Point | 101 ºC |
| Exact Mass | 176.10500 |
| PSA | 66.76000 |
| LogP | 0.07140 |
|
~%
Ketone Ester CAS#:1208313-97-6 |
| Literature: Isis Innovation Limited; Government of the USA, as Represented by the Secretary , Department of Health And; Human Services Patent: US2011/237666 A1, 2011 ; Location in patent: Page/Page column 5 ; |
| Precursor 2 | |
|---|---|
| DownStream 0 | |
| 3-hydroxybutyl-(R)-3-hydroxybutyrate |
| (3R)-hydroxybutyl (3R)-hydroxybutyrate |
| Ketone Ester |
| BD-AcAc 2 |
| Ketone Ester |
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- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: BD-AcAc2
- Price: Check
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Yang
- Email: sales@echemcloud.com
- Henan Tianfu Chemical Co., Ltd.
- China
- Product Name: (R)-3-hydroxybutyl (R)-3-hydroxybutyrate
- Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
- Purity: 99.0%
- Delivery: Inquiry
- Contact: Anson
- Email: info@tianfuchem.com
- Zhongshan Xingrui Chemical Co. , Ltd.
- China
- Product Name: Ketone Ester
- Price: ￥Inquiry/25kg
- Purity: 99.0%
- Delivery: Inquiry
- Contact: Wang Jie
- Email: 3096638339@qq.com
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Price: $567/10mM*1mLinDMSO
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