Mefenamic acid D4

Modify Date: 2024-01-10 11:10:17

Mefenamic acid D4 Structure
Mefenamic acid D4 structure
Common Name Mefenamic acid D4
CAS Number 1216745-79-7 Molecular Weight 245.310
Density 1.2±0.0 g/cm3 Boiling Point 398.8±0.0 °C at 760 mmHg
Molecular Formula C15H11D4NO2 Melting Point N/A
MSDS N/A Flash Point 195.0±0.0 °C

 Use of Mefenamic acid D4


Mefenamic acid D4 is a deuterium labeled Mefenamic acid. Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1 and hCOX-2, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively[1][2].

 Names

Name 2-[(2,3-Dimethylphenyl)amino](2H4)benzoic acid
Synonym More Synonyms

 Mefenamic acid D4 Biological Activity

Description Mefenamic acid D4 is a deuterium labeled Mefenamic acid. Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1 and hCOX-2, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively[1][2].
Related Catalog
Target

hCOX-1:40 nM (IC50)

hCOX-2:3 nM (IC50)

References

[1]. Gierse JK, et al. Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase. Biochem J. 1995 Jan 15;305 (Pt 2):479-84.

[2]. Hashemipour MA, et al. In Vitro Cytotoxic Effects of Celecoxib, Mefenamic Acid, Aspirin and Indometacin on Several Cells Lines. J Dent (Shiraz). 2016 Sep;17(3):219-25.

 Chemical & Physical Properties

Density 1.2±0.0 g/cm3
Boiling Point 398.8±0.0 °C at 760 mmHg
Molecular Formula C15H11D4NO2
Molecular Weight 245.310
Flash Point 195.0±0.0 °C
Exact Mass 245.135391
LogP 5.33
Vapour Pressure 0.0±0.0 mmHg at 25°C
Index of Refraction 1.639

 Synonyms

2-[(2,3-Dimethylphenyl)amino](2H4)benzoic acid
Benzoic-2,3,4,5-d4 acid, 6-[(2,3-dimethylphenyl)amino]-