Temephos-d12

Modify Date: 2024-01-09 18:27:28

Temephos-d12 structure	Common Name	Temephos-d12
	CAS Number	1219795-39-7	Molecular Weight	478.543
	Density	1.4±0.1 g/cm3	Boiling Point	518.5±60.0 °C at 760 mmHg
	Molecular Formula	C₁₆H₈D₁₂O₆P₂S₃	Melting Point	N/A
	MSDS	N/A	Flash Point	267.4±32.9 °C

Use of Temephos-d12

Temephos-d12 is the deuterium labeled Temephos[1]. Temefos is an organophosphate larvicide, used to treat water infested with disease-carrying insects including mosquitoes, midges, and black fly larvae. Temefos affects the central nervous system through inhibition of cholinesterase, results in death before reaching the adult stage[2][3].

Name	O,O,O',O'-Tetrakis[(2H3)methyl] O,O'-(sulfanediyldi-4,1-phenylene) bis(phosphorothioate)
Synonym	More Synonyms

Description	Temephos-d12 is the deuterium labeled Temephos[1]. Temefos is an organophosphate larvicide, used to treat water infested with disease-carrying insects including mosquitoes, midges, and black fly larvae. Temefos affects the central nervous system through inhibition of cholinesterase, results in death before reaching the adult stage[2][3].
Related Catalog	Research Areas >> Infection
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Thirugnanam M, et al. Environmental impact of mosquito pesticides: influence of temefos on the brain acetylcholinesterase of killifish. Environ Physiol Biochem. 1975;5(6):451-9. [3]. Wirth MC, et al. Selection and characterization of temephos resistance in a population of Aedes aegypti from Tortola, British Virgin Islands. J Am Mosq Control Assoc. 1999 Sep15(3):315-20.

Density	1.4±0.1 g/cm3
Boiling Point	518.5±60.0 °C at 760 mmHg
Molecular Formula	C₁₆H₈D₁₂O₆P₂S₃
Molecular Weight	478.543
Flash Point	267.4±32.9 °C
Exact Mass	478.065033
LogP	5.96
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.613

O,O,O',O'-Tetrakis[(H)methyl] O,O'-(sulfanediyldi-4,1-phenylene) bis(phosphorothioate)

Phosphorothioic acid, O,O,O',O'-tetramethyl-d O,O'-(thiodi-4,1-phenylene) ester

Temephos-d12

Use of Temephos-d12

Names

Temephos-d12 Biological Activity

Chemical & Physical Properties

Synonyms