SGD-1882
Modify Date: 2024-01-02 17:06:55
SGD-1882 structure
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Common Name | SGD-1882 | ||
|---|---|---|---|---|
| CAS Number | 1222490-34-7 | Molecular Weight | 725.788 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 977.7±65.0 °C at 760 mmHg | |
| Molecular Formula | C42H39N5O7 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 545.1±34.3 °C | |
Use of SGD-1882SGD-1882 is a cytotoxic, DNA minor-groove crosslinking agent pyrrolobenzodiazepine (PBD) dimer, acting as the payload for ADCs. |
| Name | SGD-1882 |
|---|---|
| Synonym | More Synonyms |
| Description | SGD-1882 is a cytotoxic, DNA minor-groove crosslinking agent pyrrolobenzodiazepine (PBD) dimer, acting as the payload for ADCs. |
|---|---|
| Related Catalog | |
| In Vitro | SGD-1882 is the cytotoxic payload undergoing clinical evaluation for anti-CD33 and anti-CD70 conjugates[1]. SGD-1882 is not an MDR1 substrate, and SGN-CD33A is conjugated to the SGD-1882. SGN-CD33A can kill MDR1 expressing CD33 positive AML patient samples and is currently in Phase I[2]. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 977.7±65.0 °C at 760 mmHg |
| Molecular Formula | C42H39N5O7 |
| Molecular Weight | 725.788 |
| Flash Point | 545.1±34.3 °C |
| Exact Mass | 725.284973 |
| LogP | 2.87 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Index of Refraction | 1.676 |
| 5H-Pyrrolo[2,1-c][1,4]benzodiazepin-5-one, 2-(4-aminophenyl)-8-[3-[[(11aS)-5,11a-dihydro-7-methoxy-2-(4-methoxyphenyl)-5-oxo-1H-pyrrolo[2,1-c][1,4]benzodiazepin-8-yl]oxy]propoxy]-1,11a-dihydro-7-methoxy-, (11aS)- |
| (11aS)-2-(4-Aminophenyl)-7-methoxy-8-(3-{[(11aS)-7-methoxy-2-(4-methoxyphenyl)-5-oxo-5,11a-dihydro-1H-pyrrolo[2,1-c][1,4]benzodiazepin-8-yl]oxy}propoxy)-1,11a-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one |
| SGD-1882 |
| IRE1I9FE08 |