D-Lin-MC3-DMA
Modify Date: 2024-01-04 17:47:34
D-Lin-MC3-DMA structure
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Common Name | D-Lin-MC3-DMA | ||
|---|---|---|---|---|
| CAS Number | 1224606-06-7 | Molecular Weight | 642.09300 | |
| Density | 0.886±0.06 g/cm3(Predicted) | Boiling Point | 670.2±43.0 °C(Predicted) | |
| Molecular Formula | C43H79NO2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of D-Lin-MC3-DMAD-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle. |
| Name | DLin-M-C3-DMA |
|---|---|
| Synonym | More Synonyms |
| Description | D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle. |
|---|---|
| Related Catalog | |
| In Vivo | Lipid nanoparticles (LNPs) containing distearoylphosphatidlycholine (DSPC), and ionizableamino-lipids such as dilinoleylmethyl-4-dimethylaminobutyrate (DLin-MC3-DMA) are potent siRNA delivery vehicles in vivo. LNP-siRNA systems optimize to achieve maximum gene silencing potency in hepatocytesfollowing IV administration in mice contain DLin-MC3-DMA (MC3), DSPC, cholesterol and a polyethyleneglycol (PEG)-lipid at mole ratios of 50/10/38.5/1.5. DLin-MC3-DMA exhibits an optimized pKa value that leads to dramatically enhanced potency[1]. |
| References |
| Density | 0.886±0.06 g/cm3(Predicted) |
|---|---|
| Boiling Point | 670.2±43.0 °C(Predicted) |
| Molecular Formula | C43H79NO2 |
| Molecular Weight | 642.09300 |
| Exact Mass | 641.61100 |
| PSA | 29.54000 |
| LogP | 13.64720 |
| Storage condition | -20℃ |
| (6Z,9Z,28Z,31Z)-heptatriaconta-6,9,28,31-tetraen-19-yl 4-(dimethylamino)butanoate |
| (6Z,9Z,28Z,31Z)-heptatriaonta-6,9,28,31-tetraen-19-yl 4-(dimethylamino)butanoate |
| dilinoleylmethyl 4-(dimethylamino)butanoate |
| (6Z,9Z,28Z,31Z)-heptatriaconta-6,9,28,31-tetraen-19-yl-4-(dimethylamino)butanoate |
| heptatriaconta-6,9,28,31-tetraen-19-yl-4-(dimethylamino)butanoate |
| (6Z,9Z,28Z,31Z)heptatriaconta-6,9,28,31-tetraen-19-yl-4-(dimethylamino)butanoate |
| D-Lin-MC3-DMA |