D-Lin-MC3-DMA

Modify Date: 2025-08-25 10:22:25

Use of D-Lin-MC3-DMA

D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle.

Name	DLin-M-C3-DMA
Synonym	More Synonyms

Description	D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cancer
In Vivo	Lipid nanoparticles (LNPs) containing distearoylphosphatidlycholine (DSPC), and ionizableamino-lipids such as dilinoleylmethyl-4-dimethylaminobutyrate (DLin-MC3-DMA) are potent siRNA delivery vehicles in vivo. LNP-siRNA systems optimize to achieve maximum gene silencing potency in hepatocytesfollowing IV administration in mice contain DLin-MC3-DMA (MC3), DSPC, cholesterol and a polyethyleneglycol (PEG)-lipid at mole ratios of 50/10/38.5/1.5. DLin-MC3-DMA exhibits an optimized pKa value that leads to dramatically enhanced potency[1].
References	[1]. Kulkarni JA, et al. Design of lipid nanoparticles for in vitro and in vivo delivery of plasmid DNA. Nanomedicine. 2017 May;13(4):1377-1387.

Density	0.886±0.06 g/cm3(Predicted)
Boiling Point	670.2±43.0 °C(Predicted)
Molecular Formula	C₄₃H₇₉NO₂
Molecular Weight	642.09300
Exact Mass	641.61100
PSA	29.54000
LogP	13.64720
InChIKey	NRLNQCOGCKAESA-KWXKLSQISA-N
SMILES	CCCCCC=CCC=CCCCCCCCCC(CCCCCCCCC=CCC=CCCCCC)OC(=O)CCCN(C)C
Storage condition	-20℃

(6Z,9Z,28Z,31Z)-heptatriaconta-6,9,28,31-tetraen-19-yl 4-(dimethylamino)butanoate

(6Z,9Z,28Z,31Z)-heptatriaonta-6,9,28,31-tetraen-19-yl 4-(dimethylamino)butanoate

dilinoleylmethyl 4-(dimethylamino)butanoate

(6Z,9Z,28Z,31Z)-heptatriaconta-6,9,28,31-tetraen-19-yl-4-(dimethylamino)butanoate

heptatriaconta-6,9,28,31-tetraen-19-yl-4-(dimethylamino)butanoate

(6Z,9Z,28Z,31Z)heptatriaconta-6,9,28,31-tetraen-19-yl-4-(dimethylamino)butanoate

D-Lin-MC3-DMA

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Price: $396/10mM*1mLinDMSO

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