(dimethyl)[10H-pyrido[3,2-b][1,4]benzothiazine-10-propyl]ammonium chloride

Modify Date: 2024-02-08 11:34:14

(dimethyl)[10H-pyrido[3,2-b][1,4]benzothiazine-10-propyl]ammonium chloride Structure
(dimethyl)[10H-pyrido[3,2-b][1,4]benzothiazine-10-propyl]ammonium chloride structure
Common Name (dimethyl)[10H-pyrido[3,2-b][1,4]benzothiazine-10-propyl]ammonium chloride
CAS Number 1225-65-6 Molecular Weight 321.86800
Density N/A Boiling Point N/A
Molecular Formula C16H20ClN3S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of (dimethyl)[10H-pyrido[3,2-b][1,4]benzothiazine-10-propyl]ammonium chloride


Prothipendyl hydrochloride is an orally active agent that can be used in the study of mental symptoms in the aged (e.g. anxiety)[1].

 Names

Name N,N-dimethyl-3-pyrido[3,2-b][1,4]benzothiazin-10-ylpropan-1-amine,hydrochloride
Synonym More Synonyms

  Biological Activity

Description Prothipendyl hydrochloride is an orally active agent that can be used in the study of mental symptoms in the aged (e.g. anxiety)[1].
Related Catalog
References

[1]. J F FLEETWOOD, et al. The Treatment of Mental Symptoms in the Aged With Prothipendyl (Tolnate). J Coll Gen Pract. 1964 Sep;8(2):262-6.  

 Chemical & Physical Properties

Molecular Formula C16H20ClN3S
Molecular Weight 321.86800
Exact Mass 321.10700
PSA 41.43000
LogP 1.15470

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UU8750000
CHEMICAL NAME :
10H-Pyrido(3,2-b)(1,4)benzothiazine, 10-(3-(dimethylamino)propyl)-, monohydrochloride
CAS REGISTRY NUMBER :
1225-65-6
LAST UPDATED :
199012
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C16-H19-N3-S.Cl-H
MOLECULAR WEIGHT :
321.90
WISWESSER LINE NOTATION :
T C666 BN DN ISJ B1Y1&N1&1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
610 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,292,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
115 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,292,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1323 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,292,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
110 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,292,1972

 Synonyms

(3-Benzo[b]pyrido[2,3-e][1,4]thiazin-10-yl-propyl)-dimethyl-amin,Monohydrochlorid
Dominal hydrochloride
Dominal forte
(dimethyl)(10H-pyrido[3,2-b][1,4]benzothiazine-10-propyl)ammonium chloride
N,N-dimethyl-10H-pyrido[3,2-b][1,4]benzothiazine-10-propanamine,monohydrochloride
10-(3-Dimethylaminopropyl)-1-azaphenothiazine hydrochloride
Tolnate
Prothipendyl HCl
(3-benzo[b]pyrido[2,3-e][1,4]thiazin-10-yl-propyl)-dimethyl-amine,monohydrochloride
Prothipendyl hydrochloride
Azacon
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