LCL521

Modify Date: 2025-09-10 20:21:34

LCL521 Structure
LCL521 structure
Common Name LCL521
CAS Number 1226851-11-1 Molecular Weight 592.77
Density N/A Boiling Point N/A
Molecular Formula C31H52N4O7 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of LCL521


LCL521 is an acid ceramidase (ACDase) inhibitor. LCL521 also inhibits the lysosomal acid sphingomyelinase (ASMase).

 Names

Name LCL521

 LCL521 Biological Activity

Description LCL521 is an acid ceramidase (ACDase) inhibitor. LCL521 also inhibits the lysosomal acid sphingomyelinase (ASMase).
Related Catalog
Target

ACDase, ASMase[1]

In Vitro LCL521 (1 µM) acts as a potent inhibitor of cellular ACDase activity, whereas 10 µM LCL521 has an additional, decreased affect on the α-form of this enzyme. LCL521 (10 µM) causes a time-dependent (1 hours and 5 hours) decrease of the α-ACDase form in MCF7 cells[1].
References

[1]. Bai A, et al. Targeting (cellular) lysosomal acid ceramidase by B13: design, synthesis and evaluation of novel DMG-B13 ester prodrugs. Bioorg Med Chem. 2014 Dec 15;22(24):6933-44.

 Chemical & Physical Properties

Molecular Formula C31H52N4O7
Molecular Weight 592.77
Storage condition 2-8℃
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