KCC2 blocker 1
Modify Date: 2024-01-16 17:36:05
KCC2 blocker 1 structure
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Common Name | KCC2 blocker 1 | ||
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| CAS Number | 1228439-36-8 | Molecular Weight | 415.50 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H25NO5S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of KCC2 blocker 1KCC2 blocker 1 is an orally active and selective K+-Cl- cotransporter KCC2 blocker with an IC50 of 1 μM. KCC2 blocker 1 is a benzyl prolinate and has antiepileptic effect[1]. |
| Name | KCC2 blocker 1 |
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| Description | KCC2 blocker 1 is an orally active and selective K+-Cl- cotransporter KCC2 blocker with an IC50 of 1 μM. KCC2 blocker 1 is a benzyl prolinate and has antiepileptic effect[1]. |
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| Related Catalog | |
| Target |
IC50: 1 μM (KCC2)[1] |
| In Vitro | KCC2 blocker 1 (compound 13; 100 μM) inhibits NKCC1 with 35%. |
| In Vivo | KCC2 blocker 1 (compound 13; 1 mg/kg iv and 6 mg/kg po) has a t1/2 of 0.3 hours, a CL of 26 mL/min/kg, a C max of 457 ng/mL and a AUC of 726 ng•h/mL for male Wistar rats[1]. Animal Model: Male Wistar rats[1] Dosage: 1 mg/kg or 6 mg/kg (Pharmacokinetic Analysis) Administration: IV (1 mg/kg) and PO (6 mg/kg) Result: Had a t1/2 of 0.3 hours, a CL of 26 mL/min/kg, a C max of 457 ng/mL and a AUC of 726 ng•h/mL. |
| References |
| Molecular Formula | C22H25NO5S |
|---|---|
| Molecular Weight | 415.50 |
| Storage condition | -20°C |