RV1088
Modify Date: 2025-07-26 16:19:20
RV1088 structure
|
Common Name | RV1088 | ||
|---|---|---|---|---|
| CAS Number | 1229606-73-8 | Molecular Weight | 578.661 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 706.1±60.0 °C at 760 mmHg | |
| Molecular Formula | C33H34N6O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 380.8±32.9 °C | |
Use of RV1088RV1088 is a potent narrow spectrum kinase inhibitor that target p38, c-Src, Syk or JAK individually, dose-dependently reduces TNF-α levels in LPS-activated macrophages with IC50 of 0.63 nM; also reduces IL-6 production effectively with IC50 of 1.66 nM, RV1088 is significantly more effective at inhibiting IL-6 and IL-8 production by monocytes and RA synovial fibroblasts compared with Humira; TNF-α, IL-6 and IL-8 synthesis in RA synovial membrane cells with low nM IC50s. |
| Name | 2-Methoxy-N-(4-{[4-({[1-(4-methylphenyl)-3-(2-methyl-2-propanyl)-1H-pyrazol-5-yl]carbamoyl}amino)-1-naphthyl]oxy}-2-pyridinyl)acetamide |
|---|---|
| Synonym | More Synonyms |
| Description | RV1088 is a potent narrow spectrum kinase inhibitor that target p38, c-Src, Syk or JAK individually, dose-dependently reduces TNF-α levels in LPS-activated macrophages with IC50 of 0.63 nM; also reduces IL-6 production effectively with IC50 of 1.66 nM, RV1088 is significantly more effective at inhibiting IL-6 and IL-8 production by monocytes and RA synovial fibroblasts compared with Humira; TNF-α, IL-6 and IL-8 synthesis in RA synovial membrane cells with low nM IC50s. |
|---|---|
| References | References 1. To WS, et al. Br J Pharmacol. 2015 Aug;172(15):3805-16. View Related Products by Target p38 MAPK |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 706.1±60.0 °C at 760 mmHg |
| Molecular Formula | C33H34N6O4 |
| Molecular Weight | 578.661 |
| Flash Point | 380.8±32.9 °C |
| Exact Mass | 578.264160 |
| LogP | 7.62 |
| Vapour Pressure | 0.0±2.2 mmHg at 25°C |
| Index of Refraction | 1.632 |
| 2-Methoxy-N-(4-{[4-({[1-(4-methylphenyl)-3-(2-methyl-2-propanyl)-1H-pyrazol-5-yl]carbamoyl}amino)-1-naphthyl]oxy}-2-pyridinyl)acetamide |
| Acetamide, N-[4-[[4-[[[[3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]amino]carbonyl]amino]-1-naphthalenyl]oxy]-2-pyridinyl]-2-methoxy- |