SJM-3
Modify Date: 2024-02-19 17:45:36
SJM-3 structure
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Common Name | SJM-3 | ||
|---|---|---|---|---|
| CAS Number | 1234977-97-9 | Molecular Weight | 354.401 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 568.2±60.0 °C at 760 mmHg | |
| Molecular Formula | C18H15FN4OS | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 297.4±32.9 °C | |
Use of SJM-3SJM-3 is a positive allosteric modulator of various isoforms of the GABAA receptor, specifically binding to the high-affinity benzodiazepine binding site located at the α+/γ- subunit interface. |
| Name | (6-Fluoro-2-methyl-3,4-dihydro-1(2H)-quinolinyl)[2-(2-pyrazinyl)-1,3-thiazol-4-yl]methanone |
|---|---|
| Synonym | More Synonyms |
| Description | SJM-3 is a positive allosteric modulator of various isoforms of the GABAA receptor, specifically binding to the high-affinity benzodiazepine binding site located at the α+/γ- subunit interface. |
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| In Vitro | SJM-3 binds at the high-affinity benzodiazepine binding site at theα+/γ- subunit interface but effects its action through another site presumably located within the transmembrane domain. The binding affinity of SJM-3 at wild type receptors is determined by displacement of [ 3 H]-Flunitrazepam and [ 3 H]-Ro15-1788 and indicates a K i of SJM-3 amounting to 218±70 nM and 242±38 nM, respectively[1]. |
| References | 1. Simon J Middendorp, et al. Positive modulation of synaptic and extrasynaptic GABAA receptors by an antagonist of the high affinity benzodiazepine binding site. Neuropharmacology. 2015 Aug;95:459-67. |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 568.2±60.0 °C at 760 mmHg |
| Molecular Formula | C18H15FN4OS |
| Molecular Weight | 354.401 |
| Flash Point | 297.4±32.9 °C |
| Exact Mass | 354.095062 |
| LogP | 3.01 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.630 |
| (6-Fluoro-2-methyl-3,4-dihydro-1(2H)-quinolinyl)[2-(2-pyrazinyl)-1,3-thiazol-4-yl]methanone |
| Methanone, (6-fluoro-3,4-dihydro-2-methyl-1(2H)-quinolinyl)[2-(2-pyrazinyl)-4-thiazolyl]- |