Omaciclovir

Modify Date: 2024-01-09 00:38:43

Use of Omaciclovir

Omaciclovir (H2G) is a potent and selective inhibitor of herpesvirus replication. Omaciclovir is a nucleoside analog with antiviral activity[1].

Name	2-amino-9-[(2R)-4-hydroxy-2-(hydroxymethyl)butyl]-3H-purin-6-one
Synonym	More Synonyms

Description	Omaciclovir (H2G) is a potent and selective inhibitor of herpesvirus replication. Omaciclovir is a nucleoside analog with antiviral activity[1].
Related Catalog	Signaling Pathways >> Anti-infection >> HSV Research Areas >> Infection
In Vitro	Omaciclovir is a nucleoside analog with in vitro inhibitory activity against varicella-zoster virus (VZV), herpes simplex virus types 1 and 2 (HSV-1 and -2), Epstein-Barr virus, and human herpesvirus 6. Omaciclovir is also efficacious in simian varicella virus-infected monkeys[1]. Omaciclovir shows antiviral activities against different human herpesviruses with EC50s of 0.72 ± 0.1, 0.62 ± 0.2, 0.015 ± 0.004, 0.048 ± 0.023, 0.047 ± 0.004, 0.035 ± 0.022, and 0.016 ± 0.003 μM for MRC-5 VZV-32, MRC-5 Molly, MeWo VZV-32, MeWo Molly, MeWo Emily, MeWo VZ11, and MeWo VZ30, respectively[1].
References	[1]. T I Ng , et al. Selection and Characterization of Varicella-Zoster Virus Variants Resistant to (R)-9-[4-hydroxy-2-(hydroxymethy)butyl]guanine. Antimicrob Agents Chemother. 2001 Jun;45(6):1629-36.

H2G

Omaciclovir

2-HMHBG

Omaciclovir (USAN/INN)

ABT-091

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