rac Efavirenz-d4

Modify Date: 2024-01-09 12:23:23

rac Efavirenz-d4 structure	Common Name	rac Efavirenz-d4
	CAS Number	1246812-58-7	Molecular Weight	319.700
	Density	1.5±0.1 g/cm3	Boiling Point	340.6±42.0 °C at 760 mmHg
	Molecular Formula	C₁₄H₅D₄ClF₃NO₂	Melting Point	N/A
	MSDS	N/A	Flash Point	159.8±27.9 °C

Use of rac Efavirenz-d4

(Rac)-Efavirenz-d4 ((Rac)-DMP 266-d4) is a labelled racemic Efavirenz. Efavirenz (DMP 266) is a potent inhibitor of the wild-type HIV-1 reverse transcriptase with a Ki of 2.93 nM and exhibits an IC95 of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture[1].

Name	6-Chloro-4-[(2,2,3,3-2H4)cyclopropylethynyl]-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-2-one
Synonym	More Synonyms

Description	(Rac)-Efavirenz-d4 ((Rac)-DMP 266-d4) is a labelled racemic Efavirenz. Efavirenz (DMP 266) is a potent inhibitor of the wild-type HIV-1 reverse transcriptase with a Ki of 2.93 nM and exhibits an IC95 of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Anti-infection >> Reverse Transcriptase
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Young SD, et al. L-743, 726 (DMP-266): a novel, highly potent nonnucleoside inhibitor of the human immunodeficiency virus type 1 reverse transcriptase. Antimicrob Agents Chemother. 1995 Dec;39(12):2602-5. [3]. Held DM, et al. Differential susceptibility of HIV-1 reverse transcriptase to inhibition by RNA aptamers in enzymatic reactions monitoring specific steps during genome replication. J Biol Chem. 2006 Sep 1;281(35):25712-22. [4]. Grobler JA, et al. HIV-1 reverse transcriptase plus-strand initiation exhibits preferential sensitivity to non-nucleoside reverse transcriptase inhibitors in vitro. J Biol Chem. 2007 Mar 16;282(11):8005-10.

Density	1.5±0.1 g/cm3
Boiling Point	340.6±42.0 °C at 760 mmHg
Molecular Formula	C₁₄H₅D₄ClF₃NO₂
Molecular Weight	319.700
Flash Point	159.8±27.9 °C
Exact Mass	319.052490
LogP	4.84
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.581

6-Chloro-4-[(2,2,3,3-2H4)cyclopropylethynyl]-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-2-one

2H-3,1-Benzoxazin-2-one, 6-chloro-4-[2-(cyclopropyl-2,2,3,3-d4)ethynyl]-1,4-dihydro-4-(trifluoromethyl)-

rac Efavirenz-d4

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