KS 176

Modify Date: 2025-08-26 08:26:01

KS 176 Structure
KS 176 structure
Common Name KS 176
CAS Number 1253452-78-6 Molecular Weight 405.40300
Density N/A Boiling Point N/A
Molecular Formula C22H19N3O5 Melting Point N/A
MSDS USA Flash Point N/A

 Use of KS 176


KS176 is a potent and selective inhibitor of the breast cancer resistance protein (BCRP) multidrug transporter (IC50 values are 0.59 and 1.39 μM in Pheo A and Hoechst 33342 assays respectively). Displays no inhibitory activity against P-gp or MRP1.IC50 value: 0.59( in Pheo A assay), 1.39 μM (in Hoechst 33342 assay).Target: BCRPThe more detailed information please refer to Compound 9 in the reference.

 Names

Name N-(4-(2-hydroxyethyl)phenyl)-2-(4-nitrobenzamido)benzamide
Synonym More Synonyms

 KS 176 Biological Activity

Description KS176 is a potent and selective inhibitor of the breast cancer resistance protein (BCRP) multidrug transporter (IC50 values are 0.59 and 1.39 μM in Pheo A and Hoechst 33342 assays respectively). Displays no inhibitory activity against P-gp or MRP1.IC50 value: 0.59( in Pheo A assay), 1.39 μM (in Hoechst 33342 assay).Target: BCRPThe more detailed information please refer to Compound 9 in the reference.
Related Catalog
References

[1]. Pick A, et al. Specific inhibitors of the breast cancer resistance protein (BCRP). ChemMedChem. 2010 Sep 3;5(9):1498-505.

 Chemical & Physical Properties

Molecular Formula C22H19N3O5
Molecular Weight 405.40300
Exact Mass 405.13200
PSA 124.25000
LogP 4.30340
Storage condition 2-8℃

 Safety Information

RIDADR NONH for all modes of transport

 Synonyms

KS176
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