N-methyl-N-(t-Boc)-PEG4-acid

Modify Date: 2024-01-08 08:45:27

N-methyl-N-(t-Boc)-PEG4-acid Structure
N-methyl-N-(t-Boc)-PEG4-acid structure
Common Name N-methyl-N-(t-Boc)-PEG4-acid
CAS Number 1260431-01-3 Molecular Weight 379.446
Density 1.1±0.1 g/cm3 Boiling Point 488.2±45.0 °C at 760 mmHg
Molecular Formula C17H33NO8 Melting Point N/A
MSDS N/A Flash Point 249.1±28.7 °C

 Use of N-methyl-N-(t-Boc)-PEG4-acid


N-Methyl-N-(t-Boc)-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name N-methyl-N-(t-Boc)-PEG4-acid
Synonym More Synonyms

 N-methyl-N-(t-Boc)-PEG4-acid Biological Activity

Description N-Methyl-N-(t-Boc)-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 488.2±45.0 °C at 760 mmHg
Molecular Formula C17H33NO8
Molecular Weight 379.446
Flash Point 249.1±28.7 °C
Exact Mass 379.220612
LogP 0.35
Vapour Pressure 0.0±2.7 mmHg at 25°C
Index of Refraction 1.470

 Synonyms

2,2,5-Trimethyl-4-oxo-3,8,11,14,17-pentaoxa-5-azaicosan-20-oic acid
MFCD28950776
3,8,11,14,17-Pentaoxa-5-azaeicosan-20-oic acid, 2,2,5-trimethyl-4-oxo-