Rifampicin-d3

Modify Date: 2024-04-06 16:18:44

Rifampicin-d3 structure	Common Name	Rifampicin-d3
	CAS Number	1262052-36-7	Molecular Weight	825.959
	Density	1.3±0.1 g/cm3	Boiling Point	937.4±65.0 °C at 760 mmHg
	Molecular Formula	C₄₃H₅₅D₃N₄O₁₂	Melting Point	N/A
	MSDS	N/A	Flash Point	520.7±34.3 °C

Use of Rifampicin-d3

Rifampicin-d3 (Rifampin-d3) is the deuterium labeled Rifampicin. Rifampicin is a potent and broad spectrum antibiotic against bacterial pathogens. Rifampicin has anti-influenza virus activities[1][2].

Name	Rifampicin-d3
Synonym	More Synonyms

Description	Rifampicin-d3 (Rifampin-d3) is the deuterium labeled Rifampicin. Rifampicin is a potent and broad spectrum antibiotic against bacterial pathogens. Rifampicin has anti-influenza virus activities[1][2].
Related Catalog	Signaling Pathways >> Anti-infection >> Influenza Virus Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Piriou A, et al. Fatty liver induced by high doses of rifampicin in the rat: possible relation with an inhibition of RNA polymerases in eukariotic cells. Arch Toxicol Suppl. 1979;(2):333-7. [3]. Yu J, et al. Monitoring in vivo fitness of rifampicin-resistant Staphylococcus aureus mutants in a mouse biofilm infection model. J Antimicrob Chemother. 2005 Apr;55(4):528-34. Epub 2005 Mar 2. [4]. Erokhina MV, et al. [In vitro development of rifampicin resistance in the epithelial cells]. Probl Tuberk Bolezn Legk. 2006;(8):58-61. [5]. Hamzehei M, et al. Inhibition of influenza A virus replication by rifampicin and selenocystamine. J Med Virol. 1980;6(2):169-74.

Density	1.3±0.1 g/cm3
Boiling Point	937.4±65.0 °C at 760 mmHg
Molecular Formula	C₄₃H₅₅D₃N₄O₁₂
Molecular Weight	825.959
Flash Point	520.7±34.3 °C
Exact Mass	825.423950
LogP	1.09
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.613

2,7-(Epoxy[1,11,13]pentadecatrienoimino)naphtho[2,1-b]furan-1,11(2H)-dione, 21-(acetyloxy)-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-8-[(E)-[[4-(methyl-d3)-1-piperazinyl]imi no]methyl]-, (2S,12E,14E,16S,17S,18R,19R,20R,21S,22S,23S,24E)-

(7S,9E,11S,12S,13S,14R,15R,16R,17S,18S,19E,21E)-2,15,17,27,29-Pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-[(E)-{[4-(2H3)methyl-1-piperazinyl]imino}methyl]-6,23-dioxo-8,30-dioxa-24-az atetracyclo[23.3.1.14,7.05,28]triaconta-1(29),2,4,9,19,21,25,27-octaen-13-yl acetate

Rifampicin-d3

Rifampicin-d3

Use of Rifampicin-d3

Names

Rifampicin-d3 Biological Activity

Chemical & Physical Properties

Synonyms