Lyso-Globotriaosylceramide (d18:1)

Modify Date: 2024-01-08 15:31:59

Lyso-Globotriaosylceramide (d18:1) Structure
Lyso-Globotriaosylceramide (d18:1) structure
Common Name Lyso-Globotriaosylceramide (d18:1)
CAS Number 126550-86-5 Molecular Weight 785.91400
Density 1.37g/cm3 Boiling Point 1005.8ºC at 760 mmHg
Molecular Formula C36H67NO17 Melting Point N/A
MSDS USA Flash Point 562.1ºC

 Use of Lyso-Globotriaosylceramide (d18:1)


Globotriaosylsphingosine (lyso-Gb3) inhibits the growth of fibroblasts, as well as their differentiation into myofibroblasts, and collagen expression. Globotriaosylsphingosine can be used for Fabry disease research[1].

 Names

Name Globotriaosylsphingosine from porcine blood
Synonym More Synonyms

 Lyso-Globotriaosylceramide (d18:1) Biological Activity

Description Globotriaosylsphingosine (lyso-Gb3) inhibits the growth of fibroblasts, as well as their differentiation into myofibroblasts, and collagen expression. Globotriaosylsphingosine can be used for Fabry disease research[1].
Related Catalog
References

[1]. Choi JY, et al. Lyso-globotriaosylceramide downregulates KCa3.1 channel expression to inhibit collagen synthesis in fibroblasts. Biochem Biophys Res Commun. 2015 Dec 25;468(4):883-8.  

[2]. Auray-Blais C, et al. How well does urinary lyso-Gb3 function as a biomarker in Fabry disease? Clin Chim Acta. 2010 Dec 14;411(23-24):1906-14.  

 Chemical & Physical Properties

Density 1.37g/cm3
Boiling Point 1005.8ºC at 760 mmHg
Molecular Formula C36H67NO17
Molecular Weight 785.91400
Flash Point 562.1ºC
Exact Mass 785.44100
PSA 303.93000
Vapour Pressure 0mmHg at 25°C
Index of Refraction 1.591

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport

 Articles25

More Articles
LC–MS/MS analysis of plasma lyso-Gb3 in Fabry disease

Clin. Chim. Acta 414 , 273-80, (2012)

Background Fabry disease is a complex, multisystemic and clinically heterogeneous disease, with elevated excretion of globotriaosylceramide (Gb3) and globotriaosylsphingosine (lyso-Gb3) accumulating i...

A metabolomic study reveals novel plasma lyso-Gb3 analogs as Fabry disease biomarkers.

Curr. Med. Chem. 20(2) , 280-8, (2013)

Fabry disease is an X-linked, multisystemic lysosomal storage disorder due to alpha-galactosidase A deficiency. It is characterized by the accumulation of glycosphingolipids, mainly globotriaosylceram...

In vivo tumor targeting using a novel intestinal pathogen-based delivery approach.

Cancer Res. 66(14) , 7230-6, (2006)

Efficient methods for tumor targeting are eagerly awaited and must satisfy several challenges: molecular specificity, transport through physiologic barriers, and capacity to withstand extracellular or...

 Synonyms

(2S,3R,4E)-2-Amino-3-hydroxy-4-octadecen-1-yl α-D-galactopyranosyl-(1->4)-β-D-galactopyranosyl-(1->4)-β-D-glucopyranoside