Selatinib

Modify Date: 2024-01-09 16:26:25

Selatinib Structure
Selatinib structure
Common Name Selatinib
CAS Number 1275595-86-2 Molecular Weight 565.06
Density 1.4±0.1 g/cm3 Boiling Point 740.5±60.0 °C at 760 mmHg
Molecular Formula C29H26ClFN4O3S Melting Point N/A
MSDS N/A Flash Point 401.6±32.9 °C

 Use of Selatinib


Selatinib is a reversible and orally active dual EGFR and ErbB2 inhibitor with IC50s of 13 nM and 22.5 nM, respectively. Selatinib has anticancer effects[1].

 Names

Name SELATINIB
Synonym More Synonyms

 Selatinib Biological Activity

Description Selatinib is a reversible and orally active dual EGFR and ErbB2 inhibitor with IC50s of 13 nM and 22.5 nM, respectively. Selatinib has anticancer effects[1].
Related Catalog
Target

EGFR:13 nM (IC50)

ErbB2:22.5 nM (IC50)

References

[1]. Meng-Na Wang, et al. First-in-human, phase I single-ascending-dose study of the safety, pharmacokinetics, and relative bioavailability of selatinib, a dual EGFR-ErbB2 inhibitor in healthy subjects. Invest New Drugs. 2020 Dec;38(6):1826-1835.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 740.5±60.0 °C at 760 mmHg
Molecular Formula C29H26ClFN4O3S
Molecular Weight 565.06
Flash Point 401.6±32.9 °C
Exact Mass 564.139832
LogP 4.81
Vapour Pressure 0.0±2.4 mmHg at 25°C
Index of Refraction 1.676

 Synonyms

4-Quinazolinamine, N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfinyl)ethyl]amino]methyl]-2-furanyl]-
6TLR8U8O3C
N-{3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfinyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine
SELATINIB
UNII:6TLR8U8O3C