RB-6145

Modify Date: 2024-01-12 20:27:38

RB-6145 structure	Common Name	RB-6145
	CAS Number	129448-97-1	Molecular Weight	374.03000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₈H₁₄Br₂N₄O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of RB-6145

RB-6145 is an orally active pro-drug of the hypoxic cell radiosensitizer RSU 1069. RB-6145 acts a hypoxic cell radiosensitizer and cytotoxin but reduces systemic toxicity in mice[1].

Name	1-[(2-Bromoethyl)amino]-3-(2-nitro-1H-imidazol-1-yl)-2-propanol h ydrobromide (1:1)
Synonym	More Synonyms

Description	RB-6145 is an orally active pro-drug of the hypoxic cell radiosensitizer RSU 1069. RB-6145 acts a hypoxic cell radiosensitizer and cytotoxin but reduces systemic toxicity in mice[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. S Cole, et al. Oral (po) dosing with RSU 1069 or RB 6145 maintains their potency as hypoxic cell radiosensitizers and cytotoxins but reduces systemic toxicity compared with parenteral (ip) administration in mice. Int J Radiat Oncol Biol Phys. 1991 Jul;21(2):387-95.

Molecular Formula	C₈H₁₄Br₂N₄O₃
Molecular Weight	374.03000
Exact Mass	371.94300
PSA	95.90000
LogP	2.00890

1H-IMIDAZOLE-1-ETHANOL,A-[[(2-BROMOETHYL)AMINO]METHYL]-2-NITRO-,HYDROBROMIDE (1:1)

2-Chloro-N-(2,2-dichloro-1-cyano-vinyl)-acetamide

Acetamide,2-chloro-N-(2,2-dichloro-1-cyanoethenyl)

1-(2-nitro-1-imidazolyl)-3-(2-bromoethylamino)-2-propanol hydrobromide

3,3-dichloro-2-(2-chloro-acetylamino)-acrylonitrile

RB-6145

Use of RB-6145

Names

RB-6145 Biological Activity

Chemical & Physical Properties

Synonyms