Exendin-3 trifluoroacetate salt

Modify Date: 2024-01-02 12:52:42

Exendin-3 trifluoroacetate salt Structure
Exendin-3 trifluoroacetate salt structure
Common Name Exendin-3 trifluoroacetate salt
CAS Number 130357-25-4 Molecular Weight 4202.57
Density N/A Boiling Point N/A
Molecular Formula C184H282N50O61S Melting Point N/A
MSDS USA Flash Point N/A

 Use of Exendin-3 trifluoroacetate salt


Exendin-3 is a biologically active peptides isolated from venoms of the Gila monster lizards, Heloderma horridurn .

 Names

Name EXENDIN-3
Synonym More Synonyms

 Exendin-3 trifluoroacetate salt Biological Activity

Description Exendin-3 is a biologically active peptides isolated from venoms of the Gila monster lizards, Heloderma horridurn .
Related Catalog
Target

VIP receptor, putative exendin receptor[1]

In Vitro Exendin-3 interacts with at least two receptors on guinea pig pancreatic acini; at high concentrations (>100 nM) the peptide interacts with VIP receptors, thereby causing a large increase in cAMP and stimulating amylase release; at lower concentrations (0.1-3 nM) the peptide interacts with a putative exendin receptor, thereby causing a smaller increase in cAMP of undetermined function[1].
Kinase Assay Effect of increasing concentrations of two VIP receptor antagonists on the increase in amylase release are observed with VIP, secretin, or exendin-3. Male Hartley guinea pigs Acini were incubated with VIP (1 nM), secretin (1 μM), or Exendin-3 (1 μM) for 30 min at 37°C, alone or in combination with indicated concentrations of [AcTyr, D-Phe]GRF 1-29 amide (solid symbols) or [4-Cl-D-Phe,Leu] VIP (open symbols)[1].
References

[1]. Raufman JP, et al. Exendin-3, a novel peptide from Heloderma horridum venom, interacts with vasoactive intestinal peptide receptors and a newly described receptor on dispersed acini from guinea pig pancreas. Description of exendin-3(9-39) amide, a specific exendin receptor antagonist. J Biol Chem. 1991 Feb 15;266(5):2897-902.

 Chemical & Physical Properties

Molecular Formula C184H282N50O61S
Molecular Weight 4202.57
Storage condition −20°C

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport
WGK Germany 3

 Articles6

More Articles
Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. Further evidence for an exendin receptor on dispersed acini from guinea pig pancreas.

J. Biol. Chem. 267 , 7402, (1992)

The recent identification in Heloderma horridum venom of exendin-3, a new member of the glucagon superfamily that acts as a pancreatic secretagogue, prompted a search for a similar peptide in Heloderm...

Glucagon-like peptide-1 stimulates luteinizing hormone-releasing hormone secretion in a rodent hypothalamic neuronal cell line.

J. Clin. Invest. 101 , 1334-1341, (1998)

To examine the influence of the putative satiety factor (GLP-1) on the hypothalamo-pituitary-gonadal axis, we used GT1-7 cells as a model of neuronal luteinizing hormone- releasing hormone (LHRH) rele...

Glucagon receptor knockout mice display increased insulin sensitivity and impaired beta-cell function.

Diabetes 55(12) , 3463-9, (2006)

In previous studies, glucagon receptor knockout mice (Gcgr(-/-)) display reduced blood glucose and increased glucose tolerance, with hyperglucagonemia and increased levels of glucagon-like peptide (GL...

 Synonyms

MFCD00240170