VU0360172

Modify Date: 2024-01-02 17:58:08

VU0360172 Structure
VU0360172 structure
 Common Name VU0360172
CAS Number 1310012-12-4 Molecular Weight 294.32
Density N/A Boiling Point N/A
Molecular Formula C18H15FN2O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of VU0360172


VU0360172 is a potent and selective mGlu5 receptor positive allosteric modulator with an EC50 value of 16 nM and a Ki of 195 nM, respectively. VU0360172 stimulates polyphosphoinositide (PI) hydrolysis in vivo, which is abrogated in mGlu5 receptors gene deleted mice[1].

 Names

Name VU0360172

 VU0360172 Biological Activity

Description VU0360172 is a potent and selective mGlu5 receptor positive allosteric modulator with an EC50 value of 16 nM and a Ki of 195 nM, respectively. VU0360172 stimulates polyphosphoinositide (PI) hydrolysis in vivo, which is abrogated in mGlu5 receptors gene deleted mice[1].
Related Catalog
Target

EC50: 16 nM (mGlu5 receptor)[1] Ki: 195 nM (mGlu5 receptor)[1]

References

[1]. Zuena AR, et al. In Vivo Non-radioactive Assessment of mGlu5 Receptor-Activated Polyphosphoinositide Hydrolysis in Response to Systemic Administration of a Positive Allosteric Modulator. Front Pharmacol. 2018 Jul 31;9:804.

 Chemical & Physical Properties

Molecular Formula C18H15FN2O
Molecular Weight 294.32
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Chemsrc provides VU0360172(CAS#:1310012-12-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of VU0360172 are included as well.>> amp version: VU0360172

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