BACE1-IN-1

Modify Date: 2025-08-29 06:09:45

BACE1-IN-1 structure	Common Name	BACE1-IN-1
	CAS Number	1310347-50-2	Molecular Weight	389.33
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₈H₁₄F₃N₅O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of BACE1-IN-1

BACE1-IN-1 is a potent and highly brain penetrant BACE1 inhibitor with IC50s of 32 and 47 nM for human BACE1 and BACE2, respectively.

Name	BACE1-IN-1

Description	BACE1-IN-1 is a potent and highly brain penetrant BACE1 inhibitor with IC50s of 32 and 47 nM for human BACE1 and BACE2, respectively.
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Beta-secretase Research Areas >> Neurological Disease
Target	IC50: 32 nM (human BACE1), 47 nM (human BACE2)[1]
References	[1]. Hilpert H, et al. β-Secretase (BACE1) inhibitors with high in vivo efficacy suitable for clinical evaluation in Alzheimer's disease. J Med Chem. 2013 May 23;56(10):3980-95.

Molecular Formula	C₁₈H₁₄F₃N₅O₂
Molecular Weight	389.33
InChIKey	DVMUZHLUMHPCGZ-QGZVFWFLSA-N
SMILES	CC1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)N=C(N)OCC1(F)F
Storage condition	2-8℃

Name: Inhibition of human BACE2 using MR121-labeled substrate incubated for 4 mins prior to...
Source: ChEMBL
Target: Beta-secretase 2
External Id: CHEMBL2353184

Name: Inhibition of human BACE1 using MR121-labeled substrate incubated for 4 mins prior to...
Source: ChEMBL
Target: Beta-secretase 1
External Id: CHEMBL2353183

Name: Half life in C57B1/6NJ mouse at 10 mg/kg, po
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL2353187

Name: Oral bioavailability in C57B1/6NJ mouse at 10 mg/kg
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL2353186

Name: Volume of distribution at steady state in C57B1/6NJ mouse at 10 mg/kg, po
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL2353185

Name: Selectivity ratio of IC50 for human BACE1 to IC50 for BACE1 in HEK293 cells
Source: ChEMBL
Target: Beta-secretase 1
External Id: CHEMBL2350617

Name: Reduction of amyloid beta40 level in C57B1/6J mouse brain at 30 mg/kg, po after 4 hrs...
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL2350616

Name: Selectivity ratio of IC50 for human BACE2 to IC50 for human BACE1
Source: ChEMBL
Target: N/A
External Id: CHEMBL2350615

Name: Reduction of amyloid beta40 level in C57B1/6J mouse brain at 10 mg/kg, po after 4 hrs...
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL2350614

Name: Inhibition of human BACE1 in HEK293 cells transfected with wild type APP assessed as ...
Source: ChEMBL
Target: Beta-secretase 1
External Id: CHEMBL2350618

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Price: $1315/1mg

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BACE1-IN-1

Use of BACE1-IN-1

Names

BACE1-IN-1 Biological Activity

Chemical & Physical Properties

BACE1-IN-1Bioassay

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.